饮酒与肝功能及红细胞参数的关系

Correlation of liver function and red blood cell parameters with repeat drinking in alcohol-dependent patients

目的:探讨饮酒与肝功能及红细胞参数的相关性.方法:选择我院2007-2009年住院的酒精性肝病(alcoholic liver disease,ALD)患者312例,与年龄相仿的正常非饮酒者40例作对照,进行肝功能和红细胞参数的测定,并与饮酒量和饮酒时间进行比较.结果:酒精性肝病患者丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、谷氨酰基转换酶(GGT)、甘氨胆酸(CG)和平均红细胞体积(MCV)、平均血红蛋白量(MCH)均显著高于对照组(P<0.001),而红细胞比容(HCT)显著下降(P<0.001),其变化与饮酒时间和饮酒量密切相关(r=0.61,0.59,均P<0.01).结论:长期饮酒可导致肝酶和红细胞参数异常,动态监测饮酒者GGT、ALT和AST有助于酒精性肝病的诊断,MCV可作为危险饮酒的监测指标.

AIM：To study the correlation of liver function and red blood cell parameters with repeat drinking in alcohol-dependent patients. METHODS：Three hundred and twelve alcohol-dependent patients and 40 normal subjects were selected and compared in this study. The inves-tigation included general state of health as well as liver function and red blood cell parameters. The correlation of liver function and red blood cell parameters with alcohol consumption and drinking time was then analyzed. RESULTS：Compared with normal controls,alanine transaminase （ALT）,aspartate transaminase （AST）,gamma-glutamyl transpeptidase （GGT）,cholylglycine （CG）,mean corpuscular volume （MCV） and mean corpuscular hemoglobin （MCH） rose signifi cantly,and hematocrit declined significantly in alcohol-dependent patients （all P 0.001）. The changes in these parameters are correlated with alcohol consumption and drinking time （r = 0.61 and 0.59,respectively; both P 0.01）. CONCLUSION：Repeat drinking may result in abnormal liver function and red blood cell parameters in alcohol-dependent patients. Dynamic monitoring of GGT,ALT and AST is conducive to the diagnosis of alcoholic liver disease. MCV can be used as a parameter for evaluation of dangerous alcohol drinking.