胰岛素瘤的流行病学特征及诊治经验调查3524例

Epidemiological features,diagnosis and treatment of insulinoma:an analysis of 3524 cases

目的:探讨中国近10年胰岛素瘤的流行病学特征和诊疗经验.方法:联合检索中国生物医学文献数据库和中国知网等多家中文数据库有关胰岛素瘤的文章,总结分析胰岛素瘤的流行病学特征和诊治经验.结果:中国近10年共报道3524例胰岛素瘤,男女比例为1.02∶1,平均年龄40.7岁,56.4%分布在华东、华北地区,以阵发性发作的低血糖表现为主要症状,17.6%的患者有癫痫表现.肿瘤摘(挖)除术是最主要的治疗手段.结论:胰岛素瘤主要分布在华东、华北地区,术前诊断困难,易被误诊,手术切除是治疗此病有效方法,手术以肿瘤摘(挖)除为主.

AIM：To study the epidemiological features of insulinoma in China during the last 10 years and to analyze its diagnosis and treatment. METHODS：The reports of insulinoma published from 2000 to 2009 were retrieved from various databases,such as the China National Knowledge Infrastructure （CNKI）. The epidemiological features,diagnosis and treatment of the disease were then analyzed. RESULTS：A total of 3524 patients with insulinoma were reported in China during the last 10 years. The male to female ratio was approximately 1.02：1. The mean age of patients at the time of diagnosis was 40.7 years. Paroxysmal hypoglycemia was the main clinical manifestation of insulinoma. Epileptic manifestations were found in 17.6% of the patients. Surgical resection was the most frequently used procedure for the treatment of insulinoma. CONCLUSION：Insulinoma is mainly distributed in East and North China. It is difficult to diagnose insulinoma preoperatively. Surgery is effective for the disease. Neoplastic resection is the most frequently used procedure for the treatment of insulinoma.