ENBD预防胆管多发结石ERCP术后急性胰腺炎及高淀粉酶血症65例

Effi cacy of ENBD in the prevention of post-ERCP pancreatitis and hyperamylasemia in patients with common bile duct stones: an analysis of 65 cases

目的:探讨内镜鼻胆管引流术(ENBD)预防胆总管多发结石患者内镜逆行胰胆管造影(ERCP)术后急性胰腺炎及高淀粉酶血症的价值.方法:收集我院胆总管多发结石患者141例(ENBD组65例,常规治疗组77例),比较两组并发症的发生和治疗的情况.结果:ENBD组和常规治疗组相比,术后2h及术后24h的血淀粉酶、术后高淀粉酶血症发生率及ERCP术后急性胰腺炎的发生率均有显著性差异(67.3U/L±9.1U/Lvs98.3U/L±11.2U/L,89.5U/L±13.0U/Lvs126.2U/L±14.2U/L,均P<0.01).结论:ENBD可以有效预防胆总管多发结石患者ERCP术后急性胰腺炎及高淀粉酶血症.

AIM： To investigate the value of endoscopic nasobiliary drainage （ENBD） in the prevention of postendoscopic retrograde cholangiopancreatography （ERCP） pancreatitis and hyperamylasemia in patients with common bile duct stones. METHODS： The clinical data of 141 patients with common bile duct stones, including 65 undergoing ENBD and 77 undergoing routine treatment, were retrospectively reviewed. The efficacy and complication rate were compared between the two groups. RESULTS： Serum amylase levels at 2 and 24h postoperatively were significantly lower in the ENBD group than in the routine treatment group （67.3 U/L ± 9.1 U/L vs 98.3 U/L ± 11.2 U/L, 89.5 U/L ± 13.0 U/L vs 126.2 U/L ± 14.2 U/L, both P 0.01）. The incidence of post-ERCP pancreatitis and hyperamylasemia was also signif icantly lower in the ENBD group than in the routine treatment group. CONCLUSION： ENBD can effectively prevent the occurrence of post-ERCP pancreatitis and hyperamylasemia in patients with common bile duct stones.