内毒素休克大鼠脑组织中氨基酸含量和钙含量的动态变化

The dynamic changes of amino acids and calcium contents of brain tissue in endotoxic shock rats

目的：观察内毒素休克大鼠脑皮层中氨基酸含量和钙含量的动态变化。结果：对照组大鼠平均动脉压平稳（１６５±０．６）ｋＰａ；休克组平均动脉压明显下降，６ｈ死亡率９０％，伴随平均动脉压的变化，脑系数于６ｈ显著增大（Ｐ＜０．０５），脑皮层兴奋性氨基酸含量于１ｈ及３ｈ有显著升高（Ｐ＜０．０５），钙含量于６ｈ有显著升高（Ｐ＜０．０５）。结论：内毒素休克可引起脑兴奋性氨基酸含量的持续过度增加。

AIM: To investigate the dynamic changes of amino acids and calcium contents of cortex in endotoxic shock rats. RESULTS:In the control group mean arterial blood pressure (MAP) were stable [(16.5±0.6) kPa], in the shock group MAP were decreased remarkably and the mortality at 6 hours past-shock was 90%. While MAP were changing the brain coefficients at 6 hours post-shock were increased significantly ( P <0.05) and the amino acids contents in cortex were significantly increased at 1 hour or 3 hours post-shock ( P <0.05) and calcium content at 6 hours post-shock were remarkably increased ( P <0.05). CONCLUSION: The increase of excitatory amino acids in cortex may be induced by endotoxic shock and may play an important pathophysiological role in the development of shock.