血管紧张素-转换酶基因多态性与原发性高血压关系探讨

Relationship between polymorphism of angiotensin-converting enzyme gene and essential hypertension

目的：探讨血管紧张素转换酶（ＡＣＥ）基因多态性与原发性高血压的关系。方法：用ＰＣＲ方法检测ＡＣＥ基因插入／缺失（Ｉ／Ｄ）的多态性。结果：（１）不论正常血压人群组或ＥＨＴ组的父母有否高血压，ＡＣＥ基因型和等位基因的频率分布无明显差异；（２）ＡＣＥ基因呈ＤＤ型随年龄增加而减少趋势；（３）ＥＨＴ中ＡＣＥ基因呈ＤＤ型发生脑血管并发症的风险率是Ⅱ型的３１９倍。结论：ＡＣＥ基因Ｉ／Ｄ多态性与ＥＨＴ缺乏关联；它可能是发生脑血管并发症的一个危险因子。

AIM:To evaluate the association between angiotensin-converting enzyme(ACE)gene polymorphism and essential hypertension(EHT).METHOD:A case-control study was undertaken detecting the insertion/deletion(I/D) polymorphism of ACE gene by polymerase chain reaction.RESULTS:(1)The frequency of ACE genotypes and alleles were not difference significantly between control and EHT with or without parental history of hypertension;(2)ACE DD genetype tended to decrease in subgroups with increasing age;(3)The risk ratio for the cerebrovascular disease in individuals with DD genotype was 3.19 times higher than those with Ⅱ genotype in EHT.CONCLUSION:There was lack of the association between the I/D polymorphism of the ACE gene and EHT in Chinese,whereas it may be an independent risk factor for cerebrovascular disease in EHT.