118例儿童过敏性紫癜与D-二聚体的关系探讨

Disscusion on relation of D-dimer and 118 children with anaphylactoid purpura

目的通过对过敏性紫癜(AP)患儿D-二聚体的检测,了解D-二聚体与AP的关系。方法采用单克隆抗体胶乳凝集法检测D-二聚体。结果 D-二聚体阳性率皮肤型AP占5.1%,紫癜性肾炎占9.4%,关节型AP占6.9%,腹型AP占9.4%,混合型AP占17.8%。89.5%的AP伴器官损伤患儿D-二聚体阳性。结论 D-二聚体检测可提示AP患儿是否处于高凝状态和纤溶亢进,指导临床用药,改善预后。

Objective To study the relation of D-dimer and children with anaphylactoid purpura（AP） by detecting D-dimer.Methods The monoclonal antibody latex agglutination method was used to detect D-dimer in 118 children cases of anaphylactoid purpura.Results The positive rate was 5.1% in cutaneous anaphylactoid purpura, 9.4% in anaphylactic purpura nephritis, 6.9% in joint type of anaphylactoid purpura, 9.4% in abdominal type of anaphylactoid purpura and 17.8% in mixed type of anaphylactoid purpura. D-dimer was positive in 89.5% of children patients with AP complicating organ injury.Conclusion D-dimer detection can suggest that the children patients with AP could be at hypercoagulable state and hyperfibrinolysis, which may be beneficial to clinical medication and improvement of prognosis.