摘要
目的和方法:本研究利用氧自由基所致的大鼠肺损伤模型,对肺损伤后肺表面活性物质(PS)病理改变和外源性PS替代治疗的作用进行了探讨。结果:大鼠气道滴入黄嘌呤和黄嘌呤氧化酶24h后,PaO2和胸肺顺应性显著下降;肺系数明显增高,组织学观察可见炎症性肺水肿。肺支气管灌洗液分析结果表明PS含量减少,蛋白含量增高。应用外源性PS治疗后,PaO2从处理前324±86kPa上升到475±29kPa(P<001)。结论:(1)肺损伤后的不同阶段PS的病理变化可能是不一致的;(2)外源性PS的替代治疗有明显效果。
AIM and METHOD:The change of lung function induced by oxygen free radicals and effect of exogenous surfactant replacement on oxygenation of injuried rat lungs were studied.RESULTS:P aO 2 and lung-thorax compliance measured after intratracheal instillation of xanthine and xanthine oxidase were significantly reduced.In morphological study,the increase of lung weight to body weight ratio was demonstrated,and there were perivascular edema and infiltration with neutrophils microscopically.The analysis of bronchoalveolar lavage fluid showed a reduction of surfactant and an increase of protein content.After surfactant administration to injured rats,the lung oxygenation was highly improved with an increase of P aO 2 from a means of 32.4 kPa to 47.5 kPa( P <0 01).CONCLUSION:The changes of pulmonary surfactant content differ in the stage of lung injury and that exogenous surfactant replacement therapy might be a rational approach to the treatment of acute respiratory failure caused by various factors.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第2期125-127,共3页
Chinese Journal of Pathophysiology
基金
北京市自然科学基金