期刊文献+

Ti6Al4V-AlTiN涂层材料的急性毒性试验 被引量:1

Acute toxicity test of Ti6Al4V-AlTiN coating materials
下载PDF
导出
摘要 背景:AlTiN陶瓷涂层具有高硬度、优良的摩擦磨损性能、良好的化学惰性和附着力强的特点,非常符合生物陶瓷的特征。为能够进入临床安全使用,需全面评价AlTiN涂层的急性毒性。目的:对Ti6Al4V-AlTiN涂层材料进行急性毒性试验研究,为长期毒性试验和其他毒理学试验提供参考依据。方法:将小鼠左右两侧股四头肌内无菌操作一次注入受试样品Ti6Al4V-AlTiN涂层材料,观察注入受试样品后14d动物全身情况及注射局部反应情况,试验中设置生理盐水作为阴性对照。结果与结论:小鼠两侧股四头肌内一次注射受试样品,观察14d后,受试样品各组动物体质量增长与阴性对照组差异无显著性意义。饮食、外观、分泌物、排泄物、呼吸、中枢神经系统及四肢活动无异常、注射局部无充血、红肿、无动物死亡情况及中毒现象。 BACKGROUND:AlTiN ceramic coatings have many advantages such as high hardness,excellent wear properties,good chemical inertness and strong adhesion,which are all consistent with the characteristics of bio-ceramics.To achieve the clinical safety,a comprehensive evaluation of acute toxicity AlTiN coating is needed.OBJECTIVE:To test acute toxicity of Ti6Al4V-AlTiN coating materials,and to provide a reference for long-term toxicity and other toxicological tests.METHODS:The mouse left and right femoral quadriceps muscle was injected with aseptic Ti6Al4V-AlTiN coating material,the general condition and reaction on the injection site of animals were observed at 14 days after injection,normal saline served as the negative control.RESULTS AND CONCLUSION:At 14 days after Ti6AI4V-AITiN injection into mouse quadriceps muscle on both sides,there was no significant difference in body mass growth between test sample group and negative control group.The animals showed normal diet,appearance,secretions,excretions,respiratory condition,central nervous system and limb activities,with no local congestion or swelling in the injection site,no animals died or showed poisoning.
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2010年第25期4611-4613,共3页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 贵州省科技项目(20082004)~~
  • 相关文献

参考文献5

二级参考文献26

共引文献707

同被引文献37

  • 1王宏宇,陈康敏,许晓静,张雪峰,刘桂玲.钛合金Ti-6Al-4V的磨损失效及其表面耐磨处理技术[J].轻金属,2005(5):54-58. 被引量:11
  • 2盖学周,饶平根,赵光岩,吴建青.人工关节材料的研究进展[J].材料导报,2006,20(1):46-49. 被引量:14
  • 3禹营,汪家道,陈大融.疏水表面的摩擦阻力特性研究[J].润滑与密封,2006,31(9):15-16. 被引量:13
  • 4魏强,杨巍,杨贤金,崔振铎.Ti6Al4V表面生物陶瓷涂层设计与生物活性研究[J].功能材料,2007,38(5):806-808. 被引量:1
  • 5屠振密, 李宁, 朱永明. 钛及钛合金表面处理技术和应用[M].北京:国防工业出版社, 2010.
  • 6Guo C, Zhou J, Zhao J, et al. Effect of ZrB2 on the micro-structure and wear resistance of Ni-based composite coatingproduced on pure Ti by laser cladding [ J ]. Tribology Trans-actions ,2010,54(1): 80 - 86.
  • 7Baker T N, Selamat M S. Surface engineering of Ti-6A1-4Vby nitriding and powder alloying using CW C02 laser [ J ].Materials Science and Technology, 2008,24 ( 2 ) : 189-200.
  • 8Silva G,Ueda M,Otani C,et al. Improvements of the sur-face properties of Ti6A14V by plasma based ion implantationat high temperatures [ J ]. Surface and Coatings Technology,2010,204(18/19) : 3018 -3021.
  • 9王晓楠.不同试验条件下表面微结构的摩擦学特性研究[D],南京:南京航空航天大学,2011.
  • 10Molinari A, Straffelini Q, Tesi B, et al. Dry sliding wearmechanism of the Ti-6A14V alloy [ J ]. Wear, 1997, 208(1/2) : 105-112.

引证文献1

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部