羟考酮控释片联合双膦酸盐治疗骨转移癌69例

Controlled-release oxycodone hydrochloride tablets in combination with bisphosphonates for skeletal metastases-caused pain in 69 cases

背景:盐酸羟考酮控释片属于第3阶梯用药,是治疗中重度癌痛的主要方法之一。目的:观察盐酸羟考酮控释片联合双膦酸盐治疗骨转移癌性疼痛的疗效及不良反应。方法:对69例骨转移癌患者口服盐酸羟考酮控释片治疗,在用药过程中根据疼痛缓解程度调整剂量;同时静脉滴注唑来膦酸4mg每4周1次,连续2次后评价疗效和不良反应。结果与结论:发现骨转移癌患者的骨痛完全缓解25例(36%),部分缓解37例(54%),轻度缓解7例(10%),总有效率为90%(62/69);不良反应有便秘、恶心呕吐、腹胀、厌食、嗜睡、头晕、发热、肌肉痛等。结果表明,盐酸羟考酮控释片联合双膦酸盐治疗骨转移癌性疼痛疗效确切,有效率高,不良反应轻,患者可以耐受。

BACKGROUND：Oxycodone hydrochloride is the medicine at the third step and is one of the most frequent medicines in treating severe cancer pain.OBJECTIVE：To evaluate the efficacy and side effects of controlled-release oxycodone hydrochloride tablets and bisphosphonates on the treatment of skeletal metastases.METHODS：A total of 69 patients suffering from skeletal metastases were treated with oral controlled-release oxycodone hydrochloride tablets,and the dosages were titrated according to the severity of pain.In addition,intravenous infusion of Zoledronic Acid was performed,4 mg every 4 weeks.The efficacy and side effects of the treatment were evaluated after 2 cycles.RESULTS AND CONCLUSION：Of the 69 patients,25 cases（36.2%） achieved complete remission,37 cases（53.6%） achieved partial remission,and 7 cases（10.1%） achieved minor remission.Pain relief was 89.9%（62/69）.The side effects included constipation,nausea and vomiting,abdominal distention,anorexia,lethargy,dizziness,fever and muscle pain.Results show that the treatment using controlled-release oxycodone hydrochloride tablets and bisphosphonates is safe and effective for skeletal metastases.Its side effects are minor and tolerable.