中心静脉导管引流并微波热疗联合化疗治疗恶性胸腔积液

The Clinical Observation for Malignant Pleural Effusion with Central Vascular Catheter Combined with Microwave Therapy and Chemotherapy

目的探讨微波热疗联合化疗治疗恶性胸腔积液的临床疗效。方法将60例患者随机分为对照组和治疗组。经胸腔闭式引流术排尽胸腔积液后,治疗组行胸腔内热灌注化疗,对照组仅行胸腔内化疗,治疗1月后评价疗效。结果治疗组总有效率为93.3%;对照组为63.3%;有显著性差异（P〈0.05）。治疗后Karnofsky评分70分者所占比率,治疗组（60.0%）显著高于对照组（33.3%）（P〈0.05）。两组不良反应比较,差异无统计学意义（P〉0.05）。结论微波热疗联合化疗治疗恶性胸腔积液方法简单易行,疗效显著。

Objective To detect the clinical efficacy of Malignant Pleural Effusion treated with microwave therapy and chemotherapy by central vascular catheter.Methods 60 cases with malignant pleural effusion were randomly divided in to two g roups.After exhansting effusion from pleural cavity through closed drainage,30 cases received the treatment of central vascular catheter combined with cisplatine （DDP） chemotherapy. 30 cases were treated with DDP microwave therapy and chemotherapy by central vascular catheter.We evaluated the clinical efficacy one months later. Results Total effective rate were 63.3% and 90.0% in two groups. There was obvious difference of response between the two groupes（P〈0.05）.The patients with Kamofsky score ≥70 was more in treated group （60.0%）than control group （33.3%）（P〈0.05）. There was not statistical significance about untoward reaction between two groupes （P〉0.05）.Conclusion Microwave therapy and chemotherapy by central vascular catheter in treatment of Malignant Pleural Effusion is easy and effective.