高岭土纳米管的结构表征、细胞学效应及其表面功能化修饰

Structural characterization,cytotoxicity and surface functionalization of halloysite nanotubes

首先研究了天然矿物高岭土的形貌结构和细胞学效应.采用TEM、SEM表征了高岭土纳米管的形态结构,MTT比色法研究了高岭土纳米管的细胞毒性效应.再通过基团之间的静电作用将阳离子聚合物聚乙烯亚胺负载到表面带负电的高岭土纳米管表面,并经过化学交联剂作用将靶向分子叶酸(FA)连接到功能化的高岭土纳米管表面.对功能化修饰的高岭土纳米管进行了Zeta电位和紫外可见吸收光谱的表征,结果表明:聚乙烯亚胺和叶酸成功地负载到高岭土纳米管的表面,从而形成了一种新型的功能化高岭土纳米管材料.

The morphology and cytotoxicity of nutural halloysite nanotubes were firstly characterized by TEM, SEM and MTT method. Furthermore, the halloysite nanotubes were functionalized by loading cationic polymer PEI onto the surface of nanotubes via electrostatic interactions, followed by crosslinking folic acid molecules onto the nanotubes. ZETA and UV-vis character functions demonstrated that both PEI and folic acid molecules were successfully loaded onto the halloysite nanotubes and a new kind of functionalized halloysite nanotubes were successfully synthesized.