藏药“佐太”中硫化汞含量测定的方法学考察

Study on the Method of Determination of Mercury Sulfide in Tibetan Medicine GTso Thal

目的对藏药"佐太"中硫化汞含量测定的硫氰酸盐络合滴定法进行方法学考察。方法通过不同消解体系、消解方法、消解时间等比较建立适合藏药"佐太"中硫化汞含量测定的硫氰酸盐络合滴定法。结果藏药"佐太"中硫化汞含量测定选择H2SO4-KNO3消解体系,每0.3 g佐太样品加入硫酸量10 ml,加入硝酸钾2.5 g;电炉直火加热回流消解30min,自然冷却30 min。结论用硫氰酸盐络合滴定法测定藏药"佐太"中硫化汞含量重现性好(RSD<1%,n=6)。藏药"佐太"中的硫化汞的平均回收率为100.92%,RSD为0.59%(n=6)。该方法操作简单,结果准确。

Objective To study the method of determination of mercury Sulfide in Tibetan Medicine GTso Thal.Methods By comparing the different digestion systems,digestion methods,digestion time and the other factors established the sulfocyanide complexometric titration method suitable for determination mercury sulfide in the Tibetan Medicine GTso Thal.Results The method was to choose H2SO4-KNO3 digestion system,add 10.00 ml sulfuric acid and 2.50 g potassium nitrate for 0.30 g GTso Thal sample;use furnace directly to heat and add circumfluence equipment;digestion time was 30 min,and natural cooling time was 30 min.Conclusion The method is simple and accurate with good reproducibility（RSD〈 1%,n = 6）.The average recovery of mercury sulfide was 100.92% and RSD was 0.59%（n=6）.