针刺对照西药治疗恶性肿瘤化疗后胃肠反应临床疗效的系统评价

Systematic Evaluation on Clinical Therapeutic Effect of Acupuncture for Treatment of Gastrointestinal Untoward Reaction by Malignant Tumor Chemotherapy

目的评价针刺治疗恶性肿瘤化疗后胃肠反应临床疗效及安全性,分析目前临床研究的现状。方法检索CBM数据库、CNKI数据库、维普数据库、万方数据库收集针刺对照西药治疗恶性肿瘤化疗后胃肠反应临床随机对照试验,统计学分析采用RevMan4.2.8.Cochrane系统评价手册进行质量评价。结果 6篇文献符合纳入标准,共461例患者。6篇文献采用有效率为评价指标,Meta-分析显示针刺对照西药(胃复安)治疗的组间比较差异有统计学意义[合并RR(固定效应模型)=1.69,95%CI(1.37,2.09),Z=4.93,P<0.000 01]。结论针刺治疗恶性肿瘤化疗后胃肠反应有效、安全;但因纳入文献数量有限且部分质量较低,结论尚不确定,需高质量证据来进一步验证。

Objective To assess the clinical therapeutic effect and reliability of acupuncture on gastrointestinal untoward reaction by malignant tumor chemotherapy.Methods CBM disc,CNKI data,VIP data,WANFANG data were retrieved to collect all relevant clinical randomized controlled trials（RCT） about acupuncture and medicine for treatment of gastrointestinal untoward reaction by malignant tumor chemotherapy.The data were statistically analyzed with an statistics analysis software named with RevMan 4.2.8 and quality evaluation was made by Cochrane Systematic evaluation manual.Results Six papers of RCT met the enrolled criteria.There were 461 patients in total.All the six papers were made the evaluation indexes with effective rate.Meta-analysis indicated that the effective rate had statistic significance between the acupuncture treatment and medication（Metoclopramide）,[merger RR（random effect model） = 1.69,95%CI（1.37,2.09）,Z=4.93,P〈0.000 01].Conclusion Acupuncture for treatment of gastrointestinal untoward reaction by malignant tumor chemotherapy is effective and safe.There are limited papers and some components are low quality,so the result is not definite.To verify the result needs much more high quality proof.