长沙市健康人群麻疹抗体水平分析

Analysis on Antibody Level of Measles of Healthy People in Changsha

目的了解长沙市健康人群麻疹抗体水平和人群免疫状况,为有效地实施麻疹预防措施和控制策略提供科学依据。方法 2007年对2～39岁健康人群共847人采用酶联免疫吸附试验(ELISA)法进行麻疹IgG抗体水平检测。结果麻疹抗体阳性率为91.5%,保护率42.38%,几何平均滴度(GMT)为1:409.61。不同区(县)麻疹抗体阳性率之间差异有统计学意义;男性与女性麻疹抗体阳性率之间差异无统计学意义;不同区(县)、不同年龄组保护率和几何平均滴度(GMT)之间差异有统计学意义。结论加强对个别区县麻疹疫苗接种工作的督查,在保证常规免疫覆盖率的基础上,提高冷链运转和基层接种质量,采取局部强化免疫,针对部分中学生进行麻疹疫苗的复种,减少麻疹散发病例和学校的暴发疫情,也可维持人群有较高的抗体水平。

Objective To understand the antibody level of measles and the immune status of healthy population in Changsha, and to provide a scientific basis fer the effective implementation of prevention and control measures of measles. Methods Enzymelinked immunosorbent assay （ELISA） was used to detect measles IgG antibodies of 847 healthy individuals aged between 2 and 39 years in 2007. Results The positive rate of measles antibody was 91.5 %, the protection rate was 42.38%, and the geometric mean titer （GMT） of measles IgG antibody was 1：409.61. There were statistically significant differences in the positive rate of measles antibody among different districts （counties）. No statistically significant difference was found in the positive rate of measles antibody between men and women. There were statistically significant differences in the protection rate and the GMT of measles IgG antibody among the different districts （counties） and among the differ- ent age groups. Conclusions A high antibody level can be reached by the following measures： to strengthen the supervision of measles vaccination in some districts, to improve the quality of cold chain operation and primary immunization on the basis of ensuring the routine immunization coverage, and to take a repeated immunization for some middle school students in order to reduce measles cases and outbreaks in schools.