永州地区沙门菌的分布及耐药性分析

Analysis on Distribution and Drug Resistance of Salmonella Bacteria in Yongzhou

目的调查永州市第三人民医院及道县人民医院沙门菌的流行趋势并进行耐药性分析,为临床合理应用抗生素提供依据。方法对2007-2008年两院收集的108株沙门菌采用K-B纸片琼脂扩散法进行耐药性分析。结果鼠伤寒沙门菌临床感染有上升趋势,沙门菌对亚胺培南的敏感率为100.0%,但对复方新诺明的敏感性明显下降(P<0.005)。对三代头孢菌素、复方新诺明、氟喹诺酮类及氯霉素等药物产生了不同程度的耐药。结论应加强沙门菌耐药性监测,以指导临床合理选择及使用抗生素。

Objective To investigate the prevalence and drug resistance of Salmonella bacteria in the Third People＇s Hospital of Yongzhou and People＇s Hospital of Dao County, and to provide a scientific basis for rational use of antibiotics in clinic. Methods Drug resistance surveillance was conducted on 108 strains of Salmonella collected from 2007 to 2008 by using K - B paper agar diffusion method. Results Clinical infection with Salmanella typhimurium appeared to have an as- cending tendency. The drug- susceptibility rate of Salmonella to imipenem was 100.0%, but the sensitivity of cotrimoxazole showed a significant decrease （P〈0. 005）. Salmonella showed resistant to the third- generation cephalosporins, cotrimoxazole, fluoroquinolones, chloramphenicol and other drugs. Conclusions Drug resistance surveillance should be strengthened to guide the rational choice and clinical use of antibiotics.