支原体和沙眼衣原体在非淋菌性尿道炎中的感染分布及耐药性分析

Analysis on Distribution and Drug Resistance of Mycoplasma and Chlamydia trachomatis in Patients with Non-gonococcal Urethritis

目的探讨非淋菌性尿道炎(NGU)患者支原体和沙眼衣原体(CT)的感染及支原体的耐药情况。方法用培养法对支原体(UU和Mh)进行分离鉴定和药敏试验,用单克隆抗体胶体金标法测沙眼衣原体。结果 573例标本中分离出解脲支原体(UU)267株(46.6%),人型支原体(Mh)58株(10.1%),沙眼衣原体(CT)100株(17.5%),支原体对常用药物有不同程度的耐药。结论解脲支原体(UU)是非淋菌性尿道炎的主要病原菌,支原体和衣原体可以引起混合感染,监测支原体的耐药性对指导合理用药有重要意义。

Objective To explore the distribution and drug resistance of mycoplasma and Chlamydia trachomatis in non gonococcal urethritis （NGU） patients. Methods With culture method, Ureaplasma ureal.yticum （Uu） and Mycoplasma hominis （Mh） were isolated and identified, and susceptibility testing was performed. Monoclonal antibody with colloidal gold standard method was used to detect Ohlamydia according to the original. Results Of 573 clinical specimens, 267 （46.6%） isolates were Ureaplasma urealyticum, 58 （10.1% ） isolates were Mycoplasma hominis, and 100 （ 17.5% ） isolates were Chlamydia trachomatis. Myceplasma showed varying degrees of resistance to the commonly used antibiotics. Conclusions Ureaplasma urealyticum is the main pathogen of non - gonococcal urethritis. Mycoplasma and chlamydia can cause mixed infection. It is of significance to monitor drug resistance of mycoplasma for guiding the rational use of antibiotics.