抑癌基因P27在急性白血病中作用的研究进展

Roles of tumor suppressor gene P27 in acute leukemia

P27是近年发现的一种抑癌基因,是细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitor,CDKIs)家族成员之一。作为细胞周期负调控因子,P27蛋白具有参与细胞周期调控、诱导凋亡、促进细胞分化等多种生物学功能。许多实体瘤存在着P27基因的缺失、突变和低表达,P27的表达水平与急性白血病的发生、发展、治疗、预后密切相关。P27可应用于急性白血病的靶向治疗,通过提高P27蛋白表达水平可治疗白血病。P27基因DNA甲基化研究尚处于初始阶段,急性白血病P27甲基化与基因表达的关系尚未明确,P27基因甲基化的改变能否作为白血病临床早期诊断及治疗的一个重要靶标,有待于深入探讨。

P27,a newly identified tumor suppressor gene,belongs to cyclin-dependent kinase inhibitors（CDKIs） family.As a negative cell cycle regulator,P27 possesses a verity of biological functions,including regulation of cell cycle,induction of cell apoptosis,promotion of cell differentiation,etc.P27 gene is deleted,mutant or decreased in many solid tumors,and its expression level is closely associated with the development,progression,treatment,and prognosis of acute leukemia.P27 can be used for targeted therapy of acute leukemia by raising the level of P27 protein expression in leukemia cells.P27 gene DNA methylation is only initially studied.P27 gene methylation in acute leukemia and its relation with gene expression remains unclear,and whether P27 gene methylation can serve as an important factor for early diagnosis and treatment of leukemia still needs further discussion.