帕瑞昔布钠在后路脊柱术后镇痛的疗效观察

Postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery

目的探讨帕瑞昔布钠在脊柱后路手术患者术后镇痛的临床疗效。方法全麻下行后路脊柱手术患者80例,随机分为帕瑞昔布钠组和安慰剂组,双盲对照观察。镇痛方法:手术结束所有患者给予背景镇痛液吗啡1.0 mg/mL,单次给药剂量2 ml后,帕瑞昔布钠组(40例):静脉注射帕瑞昔布钠40 mg,安慰剂组(40例)静脉注射生理盐水2 ml;术后24、48 h予相同剂量重复给药。观察VAS疼痛评分、患者满意度和不良反应。结果与安慰剂组相比,帕瑞昔布钠组术后6、12、24、48 h四个时间点VAS评分明显小于安慰机组(P<0.05)。两组满意率和不良反应发生率差异无统计学意义。结论脊柱后路术后短期应用帕瑞昔布钠镇痛,可为患者提供良好的镇痛效果。

Objective To investigate the postoperative analgesic effect of parecoxib sodium in patients with posterior spinal surgery.Methods Eighty patients undergoing posterior spinal surgery under general anesthesia were randomly divided into parecoxib sodium group and placebo group（n=40）.All the patients received a single dose of m ml morphine（1.0 mg/ml） as the background analgesia immediately after the operation.The patients in parecoxib sodium group were given 40 mg parecoxib sodium intravenously,and those in the placebo group received an equivalent volume of saline instead,and at 24 and 48 h after the operation,the same dose was repeated.The visual analog pain score,patient satisfaction and adverse reactions were recorded after the administrations.Results Compared with the placebo group,the patients in parecoxib sodium group had significantly lowered VAS score at 6,12,24,and 48 h after the operation（P0.05）.No significant differences were noted in the patient satisfaction and adverse reactions between the two groups.Conclusion Postoperative short-term use of parecoxib sodium can can provide good postoperative analgesic effect in patients undergoing posterior spinal surgery.