4,6-二氯-5-甲氧基嘧啶的合成新法

New Method for Synthesis of 4,6-Dichloro-5-methoxypyrimidine

[目的]对有机中间体4,6-二氯-5-甲氧基嘧啶的合成方法进行改进。[方法]以2-甲氧基-丙二酸二甲酯为原料经与氨气反应得到氨解中间体,再与甲酰胺环合成嘧啶环,最后氯化得到目标化合物4,6-二氯-5-甲氧基嘧啶。[结果]产物经红外、核磁、质谱确定结构,总收率达到42%。[结论]该方法条件温和,收率较高,适宜工业化生产。

[Objective]The research aimed to improve the synthesis method of 4,6-dichloro-5-methoxypyrimidine.[Method]2-methoxy dimethyl malonate was used to prepare 4,6-dichloro-5-methoxypyrimidine by aminolysis,cyclization and chlorization.[Result]The synthetic product was analyzed by IR,HNMR and MS.The overall yield was 42%.[Conclusion]Synthesis method was suitable for industrial production,because of its warm condition and higher yield.