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脐血干细胞治疗小儿脑瘫的临床安全性研究 被引量:10

Clinical Safety of Umbilical Cord Blood Stem Cells for Treatment of Children with Cerebral Palsy
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摘要 目的探讨人脐血干细胞临床治疗小儿脑瘫的安全性。方法脐血干细胞静脉输注及蛛网膜下腔注射治疗20例脑瘫患儿,比较治疗前后患儿的血常规、肝肾功能、电解质、出凝血时间有无差异。结果脑瘫患儿治疗前后红细胞总数、血红蛋白、血小板、总蛋白、尿素氮、肌酐、电解质水平以及出凝血时间比较,差异均无统计学意义(P>0.05)。患儿治疗前后白细胞计数及中性粒细胞分数、总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶水平比较,差异均有统计学意义(P<0.05);但患儿治疗前后上述各指标的异常率比较,差异均无统计学意义(P>0.05)。结论脐血干细胞治疗小儿脑瘫的临床应用是安全可行的。 Objective To explore the safety of human umbilical cord blood stem cells for clinical treatment of children with cerebral palsy.Methods Umbilical cord blood stem cells was in intravenous drip or subarachnoid injection given for twenty children with cerebral palsy.Then the results of examinations of blood routine test,liver and kidney functions,electrolytes,bleeding and clotting times were compared before and after treatment.Results No significant difference before and after treatment was found in children's levels of erythrocyte count,hemoglobin,platelets,total proteins,blood urea nitrogen,creatinine,electrolytes,bleeding and clotting times (P〉0.05).But after treatment significant differences were showed in children's levels of leukocyte count,neutrophil differentiation,total bilirubin,alanine transaminase,aspartic transaminase as compared with those before treatment (P〈0.05),However the anomaly rates for the above indexes after treatment had no significant difference as compared with those before treatment (P〉0.05).Conclusion Umbilical cord blood stem cell for treatment of children with cerebral palsy is safe and feasible in clinical application.
出处 《中国全科医学》 CAS CSCD 北大核心 2010年第17期1868-1870,共3页 Chinese General Practice
关键词 干细胞 脑性瘫痪 脐血 安全性 Stem cells Cerebral palsy Cord blood Security
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