乳腺癌钼靶X线表现与雌激素受体、孕激素受体及人表皮生长因子受体-2的关系

Relationship between mammographic feature and expression of ER,PR,C-erbB-2 in breast cancer

目的:探讨乳腺癌的钼靶X线表现与雌激素受体(ER)、孕激素受体(PR)以及人表皮生长因子受体-2(C-erbB-2)表达之间的关系。方法:将111例经手术病理证实的乳腺癌患者钼靶X线征象中的肿块、钙化、结构扭曲、毛刺与ER、PR、C-erbB-2表达情况进行比较。结果:111例中,有肿块67例(60.36%),有毛刺22例(19.82%),有钙化者41例(36.94%),有结构扭曲者21例(18.92%)。ER阳性59例(53.15%),PR阳性46例(41.44%),C-erbB-2阳性56例(50.45%)。肿块、钙化和结构扭曲与ER的表达无显著统计学意义;有毛刺组的ER阳性表达高于无毛刺组,有显著统计学意义。肿块、钙化、结构扭曲和毛刺均与PR的表达无显著统计学意义。有肿块组中C-erbB-2阳性表达低于无肿块组;有钙化组的C-erbB-2阳性表达高于无钙化组,都有显著统计学意义。结构扭曲和毛刺与C-erbB-2的表达没有显著统计学意义。结论:乳腺癌患者的钼靶X线表现可在某种程度上反映ER、PR、C-erbB-2的表达状况。

Objective： To investigate the relationship among estrogen receptor （ ER）, progesterone receptor （ PR ） and C - erbB - 2 of breast cancer mammography. Methods ： The mammographic features of 111 patients with breast cancer,including mass, calcification, structural disorder, spicule were studied comparatively with gene expression of ER,PR and C- erbB -2 detected with immunohistochemical technique. Results： In 111 cases ,67 cases were mass （60.36%） ,22 cases were spicule（ 19.82% ） ,41 cases were calcification（36.94% ） ,21 cases were structural disorder（ 18.92% ）. ER positive 59 cases （53.15%）, PR positive 46 cases （41.44%） , C - erbB - 2 positive 56 cases （50.45%）. Spicule was significantly correlated with positive expression of ER. Mass and calcification was significantly correlated with positive expression of C -erbB -2. Conclusion：The mammographic features can reflect the diagnosis value of estrogen receptor（ER） ,progesterone receptor（PR） and C- erbB- 2 certainly.