胃癌组织中Survivin、PTEN的表达及其临床相关性

Survivin,PTEN expression and its clinical significance in gastric cancer

目的:探讨胃癌组织中Survivin、PTEN的表达及其与临床病理特征的关系。方法:采用免疫组化(Elivision^(TM)plus法)检测35例胃癌及12例浅表性胃炎组织中Survivin、PTEN的表达。结果:胃癌组织中Survivin阳性率为77.1%(27/35),显著高于浅表性胃炎组16.7%(2/12)(P<0.01);PTEN阳性率为34.3%(12/35),显著低于浅表性胃炎组91.7%(11/12)(P<0.01);Survivin表达与组织分化程度、TNM分期密切相关(P<0.01);PTEN表达水平与组织分化程度、TNM分期密切相关(P<0.01)。Survivin和PTEN二者表达呈显著负相关(P<0.01)。结论:Survivin在胃癌中高表达,与组织分化程度、TNM分期呈正相关;PTEN在胃癌中表达下调,与组织分化程度、TNM分期呈负相关。联合检测Survivin和PTEN有助于判断胃癌预后,可能是临床评价胃癌恶性程度的重要指标。

Objective：To explore the Survivin,PTEN expression of gastric cancer and its relationship with clinical pathological characteristics. Methods ： By immunohistochemistry （ ElivisionTM plus France） to detect Survivin, PTEN expression in 35 cases of gastric cancer and 12 cases of superficial gastritis tissues. Results：The positive rate of Sur- vivin in gastric cancer was 77.1% （ 27/35 ）, significantly higher than superficial gastritis groupl 6.7 % （2/12） （ P 〈 0. 01 ） ; PTEN positive rate was 34.3% （ 12/35 ）, significantly lower than the superficialgastritis group 91.7% （ 11/ 12 ） （ P 〈 0.01 ） ; Survivin expression and histological grade, TNM stage was closely related （ P 〈 0. 01 ） ; PTEN expression level and histological grade ,TNM stage was closely related （P 〈 0.01 ）. Survivin and PTEN expression was significantly negatively correlated （P 〈 0.01 ）. Conclusion： Survivin is highly expressed in gastric cancer and positively correlated with histological grade, TNM stage; PTEN expression in gastric cancer is downexpressed, was negatively correlated with histological grade, TNM stage. Combined detection of Survivin and PTEN helps determine the prognosis of gastric cancer.