CYP2C19基因多态性与维吾尔族冠心病相关性

Correlation between genetic polymorphism of cytochrome P4502C19 and coronary artery disease in Uygur patients

目的：探讨细胞色素P450（CYP）2C19基因多态性与新疆维吾尔族人群冠心病的相关性。方法：采用聚合酶链反应-限制性片段长度多态性方法,对234例冠心病患者（冠心病组）和132例健康受试者（对照组）CYP2C19基因rs6583954位点进行多态性分析。结果：CYP2C19基因rs6583954位点等位基因CT在冠心病组分别为84.83%和15.17%,在对照组分别为78.79%和21.21%,2组等位基因频率差异有统计学意义（P〈0.05）;冠心病组CC基因型为73.1%,对照组为61.4%,2组比较差异有统计学意义（P=0.0201）;Logistic回归分析显示在调整了年龄、性别、高血压、糖尿病、高胆固醇血症等传统危险因素之后,CYP2C19基因多态性仍是维吾尔族冠心病发生的重要危险因素,基因型CC：OR值=3.25,95%CI为0.73~14.36;基因型CT：OR值=1.59,95%CI为0.34~7.35。结论：CYP2C19基因多态性可增加维吾尔族吸烟者冠心病的发生风险。

Objective To investigate the correlation between the polymorphism of CYP2C19 gene and Uygur patients with coronary heart disease in Xinjiang.Methods The genotypes of the CYP2C19 SNP（rs6583954） were detected with the technique of polymerase chain reaction and analyzed with restriction fragment length polymorphism in 234 patients with coronary heart disease and 132 controls.Results The frequencies of CYP2C19 C and T alleles were 84.83% and 15.17% in coronary heart disease patients,and 78.79% and 21.21% in controls,which showed significant differences between two groups（P0.05）.The frequency of CC was 73.1% in coronary heart disease patients,and 61.4% in controls,which showed a significant difference between two groups（P=0.0201）.The CYP2C19 polymorphism was still the main risk factor for coronary heart disease in Uygur patients after adjusting the traditional risk factors such as sex,age,hypertension,diabetes mellitus,and hypercholesterolemia by Logistic analysis.The OR value of genotype CC was 3.25,and the 95%CI was 0.73 to 14.36.The OR value of genotype CT was 1.59,and the 95%CI was 0.34 to 7.35.Conclusion The genetic polymorphism of CYP2C19 may increase the risk for coronary artery disease in Uygur patients.