慢性HBV感染者病原学特点与肝损害、肾损害的相关性研究

Correlation between etiology characteristic and hepatic and renal injuries in person with chronic HBV infection

目的探讨慢性HBV感染者病原学特点及其与肝损害、肾损害的相关性。方法根据慢性HBV感染者的病原学特点及有无肝损害情况,将282例慢性HBV感染者分为6组,观察其各项实验室指标的情况。结果双抗原阳性患者发生肝损害的例数多于单抗原阳性患者,差异有统计学意义(P<0.05);单抗原阳性而HBV-DNA阳性患者发生肝损害的例数多于单抗原阳性而HBV-DNA阴性患者,差异有统计学意义(P<0.01);单抗原阳性有合并症者发生肝损害的例数多于无合并症者,差异有统计学意义(P<0.01);≤18岁患者发生肾损害的例数多于>18岁患者,差异有统计学意义(P<0.01);有肝损害患者发生肾损害的例数明显多于无肝损害患者,差异有统计学意义(P<0.01)。结论慢性HBV感染者是否发生肝损害与病原学特点及有无合并症有相关性,是否发生肾损害与年龄因素及有无肝损害有相关性。

Objective To explore the etiology characteristic of chronic HBV infection and it＇s correlation with hepatic and renal injuries.Methods According to the etiology of chronic HBV infection and the presence of hepatic injury,the 282 persons with chronic HBV infection were divided into six groups to observe their laboratory indicators.Results The positive patients with double-antigen were more than them with single-antigen（P0.05）;the patients with posi-tive single-antigen and positive HBV-DNA suffered from hepatic injury more than the patients with negative HBV-DNA（P0.01）;the patients positive single-antigen complicated hepatic injury were more than theme without complications（P0.01）;the patients ≤18 years were more to oc-cur the renal injury than them 18 years were（P0.01）;the patients with hepatic injury suf-fered from renal injury were more than them without liver damage（P0.01）.Conclusion There is correlation when the patients with chronic HBV infection suffered from liver injury and the pathogenic features and the presence of complications,when they are suffered from renal injury and their age factor and the presence of liver injury.