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MicroRNA生物学功能及其在肿瘤中的作用机制 被引量：4

MicroRNA Biological Function and Mechanism of its Action in Tumor
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摘要 MicroRNA是新近发现的一类调控性小分子RNA,通过降解靶基因mRNA或者转录后抑制靶基因表达而发挥作用。目前的研究已经发现microRNA参与调控发育、细胞分化、细胞凋亡、细胞能量代谢等多种生理过程以及心血管疾病、神经系统疾病、糖尿病、肿瘤等多种病理过程。本文就microRNA的生物学功能及其在肿瘤发生、发展中的作用机制做一综述。 MieroRNAs are small noncoding RNAs that function to regulate gene expression by posttranscription regulation or degradation mRNA of target gene. MicroRNAs play important roles in homeostatic processes such as development, cell proliferation, cell apoptosis and energy metabolism and link to the development of the cancer, dia- betes, cardiovascular disease and nervous system disease. In this review, we describe the function and mechanisms of microRNA involved in tumorigenesis and tumor growth.
作者 陈国庆 赵志伟 曹霞 羊惠君
机构地区 武汉体育学院健康科学学院 四川大学华西基础医学与法医学院人体解剖学教研室
出处 《四川解剖学杂志》 2010年第2期34-37,共4页 Sichuan Journal of Anatomy
关键词 MICRORNA 基因调控 肿瘤治疗 MicroRNA Gene expression regulation Tumor therapy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献31

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同被引文献31

  • 1吴越.阿尔茨海默病发生机制的microRNA水平研究进展[J].中国老年学杂志,2014,34(12):3506-3508. 被引量：5
  • 2张小博,李艳会,李开良,张平.VEGF、MMP-2、MMP-9在胰腺癌中的表达及临床意义[J].中国老年学杂志,2014,34(2):327-329. 被引量：16
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  • 7Li M, Marin-Muller C, Bharadwaj U, et al. MicroRNAs: control and loss of control in human physiology and disease. World J Surg, 2009,33:667-684.
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  • 9Kim S, Choi M, Cho KH. Identifying the target mRNAs of microR- NAs in colorectal cancer. Comput Biol Chem, 2009,33:94-99.
  • 10Lea MA. Recently identified and potential targets for colon cancer treatment. Future Oncol, 2010,6:993-1002.

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四川解剖学杂志
2010年 第2期

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