乌司他丁对脓毒性休克患者血乳酸浓度的影响

The effects of Ulinastin on plasma lactate level in patients with septic shock

目的观察乌司他丁对脓毒性休克患者血乳酸浓度的影响并探讨其作用机制。方法将76例脓毒性休克患者随机分成AB两组，A组（n=38）为治疗组，B组（n=38）为对照组，两组患者均按照2004年拯救严重脓毒血症和感染性休克治疗指南处理，A组加用乌司他丁20万单位＋生理盐水20mL静脉注射，8h／次，连续应用1周，分别于入院后立即（T0）、6h（T6）、12h（T12）、24h（T24）和48h（T48）检测静脉血乳酸浓度。结果A组L和T．，时相的血乳酸浓度较B组明显减少（P〈0．05），A组的MODS发生率和病死率笔者所在科室亦较B组明显下降（P〈0．05）。结论蛋白酶抑制剂-乌司他丁可以减少脓毒性休克患者早期的血乳酸浓度，降低其MODS几率和病死率笔者所在科室。

Objective To observe the effects of Ulinastin on plasma lactate level in patients with septic shock and explore it＇s mecha- nisms. Methods Seventy - six patients with septic shock were randomly divided into two groups ： A group was treatment group （ n = 38 ） , B group was control group（ n = 38 ）. All patients in two groups were treated according the Guardline of 2004 reseueing severe septic shock. The patients in group A were received Ulinastatin 200000 Units intravenous once every eight hours and continued for one week in addiction. Plasma lactate level were measured respectively at 0, 6, 12, 24, and 48 hours. Results In comparison with group B , the Plasma lactate level at T6 and T12 were de- creased obviously （P 〈 0. 05 ） , and the rate of MODS and mortality decreased obviously （P 〈 0. 05 ） in group A. Conclusion Tryspin inhibitors - Ulinastatin can reduce the Plasma lactate level of earily stage and lower the rate of MODS and mortality in patients with septic shock.