摘要
目的探讨基质金属蛋白酶诱导因子(EMMPRIN)和基质金属蛋白酶-2(MMP-2)在胰腺癌组织表达及其临床意义。方法采用免疫组织化学PV 6000法检测47例胰腺癌组织中EMMPRIN和MMP-2的表达。结果 47例胰腺癌组织中EMMPRIN及MMP-2的阳性表达率分别为61.7%、66.0%,二者均与胰腺癌的转移、临床分期和预后有关(χ2=6.61~9.91,P<0.05)。EMMPRIN和MMP-2阳性表达率与胰腺癌大小、病人性别、病人年龄和组织学分级无关(P>0.05)。胰腺癌组织中EMMPRIN的表达与MMP-2的表达呈正相关(r=0.516,P<0.01)。结论 EMMPRIN和MMP-2可能共同参与胰腺癌的浸润和转移过程,可作为判断胰腺癌生物学行为的参考指标。
Objective To investigate the significance of EMMPRIN and MMP-2 expressions in pancreatic carcinoma.Methods Immunohistochemical PV 6000 technique was used to detect the expressions of EMMPRIN and MMP-2 in tissue of 47 cases of pancreatic carcinoma. Results The positive rates of EMMPRIN and MMP-2 were 61.7% and 66.0%,respectively,both were related with metastasis,clinical staging and prognosis(χ2=6.61-9.91,P0.05).The expressions of EMMPRIN and MMP-2 were not correlated with sex and age of patients and tumor size or histologic grading(P0.05).There was a positive correlation between the expressions of EMMPRIN and MMP-2 in the tissue of pancreatic cancer(r=0.516,P0.01). ConclusionBoth EMMPRIN and MMP-2 may be involved in the process of infiltration and metastasis of cancer of pancreas.Detection of EMMPRIN and MMP-2 can be used as parameters for the diagnosis of this malignant tumor.
出处
《齐鲁医学杂志》
2010年第4期300-302,共3页
Medical Journal of Qilu
关键词
胰腺肿瘤
基质金属蛋白酶类
明胶酶A
肿瘤转移
预后
免疫组织化学
pancreatic neoplasms
matrix metalloproteinases
gelatinase A
tumor metastasis
prognosis
immunohistochemistry