固定矫治病人龈沟液及其sICAM-1含量的检测

GINGIVAL CREVICULAR FLUID LEVEL AND sICAM-1 CONTENT IN PATIENTS WITH FIXED ORTHODONTAL TREATMENT

目的通过对固定正畸病人不同矫治时期牙周临床指标、龈沟液(GCF)及GCF中可溶性细胞间黏附分子-1(sICAM-1)的含量进行测定,探讨固定矫治对牙周组织的影响。方法随机选择口腔正畸科门诊牙齿拥挤错病人31例(男12例,女19例,年龄12～17岁),分别于矫治开始前1周,矫治开始后1、4、8周,记录16、21、23、36、41、43牙的近中颊侧共186个位点牙周临床指标,滤取并称量GCF,ELASE法检测sICAM-1的含量。结果与矫治前1周相比,矫治中各项牙周临床指标和GCF、sICAM-1的含量均呈现不同程度的上升趋势,其中牙龈指数(GI)和探诊深度(PD)矫治开始后1、4、8周与矫治前比较差异均有显著性(t=7.21～8.05,P<0.01);GCF量矫治开始后1、4、8周与矫治前比较差异均有显著性(t=15.18～25.37,P<0.001);GCF中sICAM-1的含量矫治开始后4、8周与矫治前比较差异有显著性(t=5.54～14.93,P<0.001)。结论固定正畸对病人牙周组织的健康有一定的影响。

Objective To investigate the periodontal health associated with placement of orthodontic appliances by measuring clinical parameters relating to periodontal condition,and the level of soluble intercellular adhesion molecule-1（sICAM-1） in gingival crevicular fluid（GCF）. Methods Thirty-one patients with malocclusion（12 males and 19 females ages 12-17 years） were recruited from the orthodontic clinic.Clinical indices of periodontal condition on 186 sites from tooth No.16,21,23,36 and 43 were recorded 1 week before and 1,4,and 8 weeks after treatment.GCF was collected and filtered,and sICAN-1 level determined with ELISA. Results After orthodontic treatment,various clinical indices of periodontal condition,the level of GCF and sICAM-1 showed increasing tendency compared with before the treatment.Gingival index（GI） and probing depth（DP） of 1st,4th and 8th week after treatment were significantly different from those before the treatment（t=7.21-8.05,P0.01）.GCF collected 1,4 and 8 weeks after treatment were significantly different from those of before treatment（t=15.18-25.37,P0.001）.sICAM content in GCF 4 and 8 weeks after treatment were significantly different from those before the treatment（t=5.54-14.93,P0.001）. Conclusion Fixed orthodontic treatment affects periodontal tissue condition of the patients.