抗心磷脂抗体在结缔组织疾病合并心脏损害中的临床意义

The Clinical Significance of Anticardiolipin Antibody in Treating the Connective Disease Patients with Cardiovascular Involvement

目的:初步分析抗心磷脂抗体(ACL)在系统性红斑狼疮(SLE)和干燥综合征(SS)合并心脏受累中的临床意义。方法:对84例SLE和48例SS患者进行心脏超声心动图、心电图、ACL检测,将SLE和SS按心脏超声心动图和心电图检查结果分为心脏受累组和非心脏受累组,比较SLE和SS心脏受累和无心脏受累组ACL的阳性率及意义。结果:ACL在心脏受累组的SLE患者与无心脏受累组的SLE患者之间差异无统计学意义(P>0.05),ACL在SS心脏受累组阳性率高于SS非心脏受累组(P<0.05)。结论:ACL对SS合并心脏受累有诊断意义。

Objective： To explore the correlation between the serum anticardiolipin antibodies（ACL） level and cardiovascular events in systemic lupus erythematosus（SLE） and Sjogren syndrome（SS）.Methods： 84 patients with SLE and 48patients with SS were examined with ECG,heart color Doppler and ACL,who were divided into cardiac involvement group and non-cardiac involvement group according to their diagnostic results of ultrasound examination.The positive rate of ACL and its significance were compared between the two groups.Results： No difference was found in the level of ACL between SLE cardiac involvement group and non-cardiac involvement group（P0.05）.The positive rate of ACL level in cardiac involvement group was significantly higher than that in non-cardiacinvolvement group（P0.05）.Conclusions： ACL level is of diagnostic significance for SS cardiac involvement.