固本化痰定眩方对痰浊眩晕家兔治疗作用的实验研究

Experimental Research of Guben Huatan Dingxuan Decoction on Rabbits with Vertigo of Phlegm-Retention Syndrome Type

目的:探索固本化痰定眩方治疗实验性痰浊眩晕家兔的作用机制。方法:将40只家兔分为正常组、模型组、固高组、固低组、西药组5组。高脂饮食喂养结合左侧颈椎旁硬化剂注射的方法制作痰浊眩晕家兔模型。分别检测血脂、椎动脉组织病理学、眼震持续时间及椎-基底动脉血流速度变化。结果:与模型组相比较,固本化痰定眩方高、低剂量组均能降低家兔血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平(P<0.01);固本化痰定眩方高剂量组能减轻椎动脉病理学改变,延长眼震持续时间(P<0.05),明显改善椎-基底动脉血流速度。结论:调节血脂代谢,延缓动脉粥样硬化(AS)的发展,改善椎-基底动脉系统血供,增加前庭敏感性是固本化痰定眩方治疗眩晕的可能机制。

Objective：To explore the mechanism of Guben Huatan Dingxuan Decoction（GBHTDXD）in treating Rabbits with Vertigo of phlegm-Retention Syndrome Type.Methods：Forty normal rabbits were randomly divided into five groups：normal control group,untreated group,high-dose GBHTDXD-treated group,low-dose GBHTDXD-treated group and Sibeline-treated group.Vertigo of phlegm-Retention Syndrome Type was induced in rabbits of the latter 4 groups by feeding the high lipid diet and injecting tissue sclerosing remedy.After two weeks＇treatment,Levels of blood lipid,the microstructure of the vertebral artery,the duration of nystagmus and the vestibular blood supply were observed.Results：Comparing with model group,the low-,high-dose GBHTTMR-treated can decrease the level of TC,TG and LDL-C（P〈0.01）.High-dose GBHTDXD-treated can increase the duration of nystagmus（P〈0.05）,increse the vestibular blood supply and delay the pathological changes in vertebral artery.Conclusions：GBHTDXD can decrease the level of blood lipid,and inhibit the formation of Atheroscleriosis.It also can and increase the velocity in Basilar artery and the duration of nystagmus so as to recover the vestibular function.It might be the mechanism of GBHTDXD in treating Vertigo.