Secretagogin在胃肠道类癌诊断中的作用

THE EFFECT OF SECRETAGOGIN ON THE DIAGNOSIS OF GASTROINTESTINAL CARCINOID

目的探讨Secretagogin在胃肠道类癌诊断中的作用。方法采用免疫组织化学技术检测27例胃肠道类癌(6例非典型类癌)中Secretagogin、嗜铬素A(CgA)、突触素(Syn)、神经元特异性烯醇化酶(NSE)的表达,分析其表达差异性;并比较它们在典型类癌与非典型类癌中表达情况。结果胃肠道类癌组织中Secretagogin、Syn、CgA、NSE的阳性表达率分别为96.3%、100.0%、40.7%、81.5%,四者之间差异有统计学意义(χ2=23.7,P<0.01)。CgA在非典型类癌中的表达高于典型类癌(Z=-2.098,P<0.05),其余三者均无差别。结论在绝大多数胃肠道类癌组织中Secretagogin呈阳性表达,且表达程度高于CgA;Secretagogin可以作为一个新的神经内分泌标记物用于临床胃肠道类癌的诊断。

Objective To assess the value of Secretagogin in the diagnosis of gastrointestinal carcinoid. Methods The expressions of Secretagogin,synaptophysin（Syn）,chromogranin A（CgA） and neuronspecific enolase（NSE） in 27 cases（six were untypical） of gastrointestinal carcinoid（GC） were detected immunohistochemically. Results The positive expression rate of Secretagogin,Syn,CgA and NSE in carcinoid was 96.3%,100.0%,40.7% and 81.5%,respectively.The differences among the four items were significant（χ^2=23.7,P0.01）.CgA expression in untypical carcinoid was higher than that in typical one（Z=-2.098,P0.05）,for the rest three markers,there was no significant difference among them. Conclusion Secretagogin positively expresses in the most majority of carcinoid,and its expression is stronger than that of CgA.Secretagogin can be used as a novel neuroendocrinal marker in the diagnosis of carcinoid of gastrointestinal tract.