5-取代嘧啶核苷类似物的设计、合成及生物活性研究进展

Progress in the Design,Synthesis and Biological Studies of Novel 5-Substituted Pyrimidine Nucleoside Mimics

综述了近年来有关新型5-取代嘧啶核苷类似物作为潜在生物活性先导化合物的设计、合成及生物活性研究进展.该类先导物的设计与合成主要通过以下两个方面来完成:一是在嘧啶碱基的5位上引入不同的取代基;二是在嘧啶碱基5位上引入取代基的同时对核苷中的糖基进行修饰,以得到新的衍生物.本文从以上两个方面出发,介绍了近年来这一研究领域所取得的主要进展.

The recent development on the design,synthesis and biological studies of novel 5-substituted pyrimidine nucleosides as potential antiviral,anti-tumor,antibacterial and antileishmanial agents is reviewed.