回肠Na^+/胆汁酸转运体(IBAT)及相关疾病
摘要
随着人们生活水平的提高和饮食习惯的改变,脂质代谢紊乱及相关性疾病呈现明显的上升趋势。胆汁酸循环在胆固醇代谢中扮演着非常重要的角色。而回肠末端的主动转运过程也是胆汁酸主要成分牛磺酸结合胆酸的唯一吸收方式。本文就回肠Na^+/胆汁酸转运体(iled bile acid transporter,mAT)与相关疾病的研究作一综述。
出处
《泸州医学院学报》
2010年第3期330-333,共4页
Journal of Luzhou Medical College
参考文献36
-
1Roma MG,Crocenzi FA,Sanchez Pozzi EA.Hepatocellular transport in acquired cholestasis:new insights into func-tional,regulatory and therapeutic aspects[J].Clin Sci (Lond),2008 May;114(9):567.
-
2Mareninova O,Shin JM,Vagin O.Topography of the membrane domain of the liver Na + dependent bile acid transporter[J].Biochemistry,2005 Oct; 44(42):702.
-
3Sinha J,Chen F,Miloh T.Beta klotho and FGF-15/19 inhibit the apical sodium dependent bile acid transporter in enteroc-ytes and cholangiocytes[J].Am Physiol Gastrointest Liver Phy-siol,2008 Nov;295 (5):G996-G1003.Epub 2008 Sep 4.
-
4Gill RK,Alrefai WA.Bile acid transporters:regulation and pathophysiological implications[J].Pharm Res.2008 Oct;24 (10):1752.
-
5Kramer W,Girbig F,Glombik H,et al.Identification of aligan-dbinding site in the Na+/bile acid cotransporting protein from rabbit ileum[J].Biol Chem,2004;276:36020.
-
6Brown WV.Therapies on the horizon for cholesterol reduction[J].Clin Cardiol,2001 ;24(81):24.
-
7Dawson PA,Hubbert M,Haywood J.The heteromeric organic solute transporter alphabeta,Ostalpha Ostbeta,is an ileal basolate ral bile acid transporter[J].Biol Chem,2005 Fe;25 280 (8):6960.
-
8Chignard N,Mergey M,Veissiere D,et al.Bile acid transport and regulating functions in the human biliary epitheli-um[J].Hepatology,2004;33:496.
-
9Shneider BL.Intestinal bile acid transport:biology,physiology and pathophysiology[J].Podiatr Gastroenterol Nutr,2001 ;32:407.
-
10Kramer W,Girbig F,Glombik H,et al.Identification of aligandbinding site in the Na +/bile acid cotransporting protein from rabbit ileum[J].Biol Chem,2001;276:36020.
-
1冯俊,赵平武,罗亮,贺凯,李波,夏先明.回肠Na^+/胆汁酸转运体与高脂血症关系的研究[J].泸州医学院学报,2011,34(6):640-643. 被引量:2
-
2徐如彬,陈惠德,汤健.颈椎病与骨质疏松症相关性研究进展[J].颈腰痛杂志,2003,24(6):373-375. 被引量:8
-
3唐东昕,齐越峰,金亚弦,杨柱.颈心综合征的研究进展[J].贵阳中医学院学报,2007,29(6):59-60. 被引量:3
-
4独行业,周正明,殷小军,徐耀增.抗旋股骨近端髓内钉治疗老年股骨转子周围骨折的疗效[J].中国老年学杂志,2013,33(10):2275-2276. 被引量:5
-
5胡敏,伍汉文,超楚生,杨连粤,熊寿芝,庄赞根,黄喻适,曹亦洪,李炎升.胆石症患者手术前后血清甘氨酸结合胆酸和T_3的变化及其临床意义[J].湖南医科大学学报,1997,22(2):162-164. 被引量:2
-
6柳椰,邬波,李微,宋杨.胸腰椎骨折合并截瘫治疗体会[J].辽宁中医杂志,2005,32(6):567-567.
-
7戴智勇,谭桂山,钱康年,陈萱.反相高效液相色谱法测定人胆汁中八种结合胆酸[J].湖南医科大学学报,1997,22(4):360-362. 被引量:1
-
8胡汉,刘铭,王宇,刘松波.关节镜诊治髋关节创伤相关性疾病的疗效分析[J].临床军医杂志,2016,44(9):886-888. 被引量:5
-
9徐大毅.肝脏和肾脏相关性疾病[J].临床医药实践,2002,11(8):563-565.
-
10金恩芸,许国强.胆道胆固醇高分泌的形成机制[J].国外医学(消化系疾病分册),2004,24(5):261-264. 被引量:2