干扰素与阿德福韦酯治疗慢性乙型肝炎的效果比较

CLINICAL OBSERVATION OF THE EFFECTS OF INTERFERON AND ADEFOVIR DIPIVOXIL ON PATIENTS WITH CHRONIC HEPATITIS B

目的观察比较干扰素与阿德福韦酯治疗慢性乙型肝炎的疗效及不良反应。方法选择HBeAg阳性的慢性乙型肝炎病人43例,随机分为干扰素组和阿德福韦酯组,检测病人治疗前后肝功能、肾功能、乙肝五项、HBV-DNA、血常规及甲状腺功能变化。结果干扰素组与阿德福韦酯组疗效无明显差异(P>0.05);干扰素组粒细胞减少及流感样症状发生率较高,与阿德福韦酯组比较差异有统计学意义(χ2=19.88、39.17,P<0.05),其他不良反应两者无明显差异(P>0.05)。结论干扰素和阿德福韦酯治疗慢性乙型肝炎的疗效相当,但阿德福韦酯的不良反应相对更少。

Objective To observe and compare the efficacy and side effects of interferon and adefovir dipivoxil in the treatment of patients with chronic hepatitis B. Methods Forty-three patients with HBeAg-positive chronic hepatitis were randomly divided into interferon group and adefovir dipivoxil group.The liver function,renal function,indicators of hepatitis B,HBV-DNA,routine blood test and thyroid function,before and after treatment,were detected. Results No significant difference was recorded between the two groups in terms of the therapeutic efficacy（P0.05）.The incidence of granulopenia and influenza-like symptoms was higher in the interferon group than that in the adefovir dipivoxil group（χ2=19.88,39.17;P0.05）,the differences of other side effects were not significant between the two groups（P0.05）. Conclusion The efficacy of interferon and adefovir dipivoxil for chronic hepatitis B is about the same,but the side effects of adefovir dipivoxil is lower.