安神睡宝颗粒剂的质量分析

The quality analysis of Anshen Shuibao granules

目的：建立安神睡宝颗粒剂的质量分析方法。方法：采用薄层色谱法对安神睡宝颗粒剂中的丹参、黄连、酸枣仁三味药材进行了鉴别,以高效液相色谱法对其君药丹参中的丹参酮ΙΙA进行含量测定。结果：定性分析分离度好,专属性强;丹参酮ΙΙA的含量测定线性范围为5.63~90.08μg.mL-1（R=0.9999）,平均回收率为98.85%,RSD=0.35%。结论：所建立之方法可靠、准确、专属性强,可有效控制安神睡宝颗粒剂的质量。

Objective：To establish the quality analysis method for Anshen Shuibao granules.Methods：Thin-layer chromatography（TLC） was employed to identify Salvia,Coptis chinensis and Spine Date Seed,while high performance liquid chromatography（HPLC） was applied for the determination of tanshinoneΙΙA in Salvia which was the monarch drug.Results： The identification by TLC was distinct and highly specific.The assay of had the linear tanshinoneΙΙA range of 5.63-90.08μg·mL-1（R=0.9999）,The average recovery was 98.85%,RSD was 0.35%.Conclusions： The method is reliable,accurate and specific and can be used for quality control of Anshen Shuibao granules.