期刊文献+

不同病程的单相抑郁症患者颅脑CT值的研究 被引量:3

Cerebral CT value in patients with unipolar depression of different courses
下载PDF
导出
摘要 目的探讨单相抑郁症患者各脑叶CT值的改变与病程的关系。方法对不同病程的100例单相抑郁症患者进行颅脑CT扫描,测量各脑叶的CT值,并与100例正常人进行对照比较。结果 1.患者组的左额叶CT值(40.22±1.80)比正常对照组(41.37±1.25)明显减小,差异有显著性(P<0.01),而右额叶CT值无明显差异(P>0.05);左、右颞叶CT值(40.13±2.82)、(44.53±2.99)比正常对照组(41.25±2.59)、(45.38±2.82)明显减小,差异有显著性(P<0.01)。2.患者组左额叶CT值与年龄(Beta=-0.319、P<0.01)、病程(Beta=-0.355、P<0.01)成负相关,右额叶CT值与年龄(Beta=-0.218、P<0.01)成负相关,而与病程无显著相关性(P>0.05);余各脑叶未发现与病程等有相关性。结论与正常人相比,单相抑郁症患者左额叶(优势半球)、颞叶萎缩,且左额叶萎缩程度与病程有关,提示抑郁症或许是中枢神经系统的退行性疾病。 Objective To explore the changes of CT value in cerebral lobes in patients with unipolar depressive disorder and its relation with duration. Methods Cerebral CT was performed in 100 patients with unipolar depressive disorder. CT value of all cerebral lobes were compared with the results of 100 normal subjects. Results 1. Left frontal CT value of the unipolar depression(40.22 ± 1.80) was significantly smaller than that of control group(41.37± 1.25), while there had no significant difference in right frontal index. 2. Left frontal CT value was significantly positively related to age( Beta = - 0. 319 ,P 〈 0.01 ) and duration of depression ( Beta = - 0.355 ,P 〈 0.01 ), and right frontal index was significantly positively related to age( Beta = -0.218 ,P 〈0.01 ) ,while had no gignificant correlation with duration of u- nipolar depression(P 〉 0.05). Conclusion Compared with normal subjects, the atrophy would be present in the left frontal( dominant semi -sphere) and temporal lobe of unipolar depression, and the degree of atroply may be associated with duration of depression. It may sugest that depreesion is a degenerative disease of central nervous system.
出处 《精神医学杂志》 2010年第3期186-188,共3页 Journal of Psychiatry
关键词 单相抑郁症 病程 颅脑CT CT值 Unipolar depression Duration Cerebral CT CT value
  • 相关文献

参考文献14

  • 1Coffey CE,Figiel GS,Djang WT,et al.Subcortical hyperintensity on magnetic resonance imaging:A comparison of normal and depressed elderly subjects[J].Am J Psychiatry,1990,147:187-189.
  • 2Brarabilla P,Nicoletti MA,Harenski K,et al.Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects[J].Neuropsychoparmacology,2002,27:792-799.
  • 3Kumar A,Jin Z,Bilker W,et al.Late-onset minor and major depression:early evidence for common neuroanatomical substrates detected by using MRI[J].Acad Sci,1998,95:7654 -7658.
  • 4张作记.行为医学量表手册[J][J].中国行为医学科学,2001,10:19-24.
  • 5Drevets WC,Price JL,Simpson JRJ,et al.Subgenual prefrontal cortex abnormalities in mood disorders[J].Nature,1997,386:824-827.
  • 6Coffman JA,Bornstein RA,Olson SC.Cognative impairment and cerebral structure by MRI in bipolar disorder[J].Biol Psychiatry,1990,27:1188-1196.
  • 7Botteron KN,Raichle ME,Drevets WC,et al.Volumetric reduction in left subgenual prefrontal cortex in early onset depression[J].Biol Psychiatry,2002,51:342.
  • 8汤艳清,谢光荣.抑郁症的脑结构影像学改变及其机制的研究进展[J].中国临床心理学杂志,2005,13(3):366-369. 被引量:38
  • 9李丽,董奇.抑郁症的脑神经结构和功能改变研究[J].中国临床心理学杂志,2006,14(1):106-108. 被引量:18
  • 10Strakowski SM,DelBello MP,Sax KW,et al.Brain magnetic resonance imaging of structural abnormalities in bipolar disorder[J].Arch Gan Psychiatry,1999,56:254-260.

二级参考文献67

  • 1袁浩龙.老年期的抑郁与痴呆[J].临床精神医学杂志,1996,6(2):111-114. 被引量:7
  • 2陈树林,刘军,李凌江,夏薇薇,胡德文,张锦黎.创伤后应激障碍患者脑结构的磁共振研究[J].中华精神科杂志,2006,39(1):9-11. 被引量:10
  • 3Rajkowska G, Miguel-Hidalgo JJ, Wei J, et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry, 1999, 45:1085-1098
  • 4MacQueen GM, Campbell S, McEwen B, et al. Course of illness, hippocampal functional and volume in major depression. Proc Natl Acad Sci USA, 2003, 100:1387-1393
  • 5Frodl T, Meisenzahl E, Zetzsche T, et al. Enlargement of the amygdale in patients with a first episode of major depression. Biol Psychiatry, 2002, 51:708-714
  • 6Keller SS, Wilke M, Wieshmann UC, et al. Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporallobe epilepsy. Neurohnage, 2004, 23:860-868
  • 7Ballmaier M, Toga AW, Blanton RE, et al. Anterior cingulated,gyrus rectus, and otbitofrontal abnormalities in eiderly depressed patients:An MRI-based parcellation of the prefrontal cortex. Am J Psychiatry, 2004, 161:99-108
  • 8Duman RS. Novel therapeutic approaches beyond the serotonin receptor. Biol Psychiatry, 1998, 44:324-335
  • 9Escalona PR, Early B, McDonald WM. Reduction of cerebellar volume in major depression:A controlled magnetic resonance imaging study. Depression, 1993, 1:156-158
  • 10Frodl T, Schaub A, Banac S, et al. Reduced hippocampal volume correlates with executive dysfunctioning in major depression. J Psychiatry Neurosci, 2006, 31:316-325

共引文献643

同被引文献16

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部