联苯苄唑凝胶联合维A酸乳膏治疗马拉色菌毛囊炎98例

98 cases report of bifonazole gel with tretinoin cream in the treatment of Malassezia folliculitis patients

目的:评价联苯苄唑凝胶联合维A酸乳膏治疗马拉色菌毛囊炎临床和真菌学的疗效。方法:随机分成两组,治疗组98例,采用联苯苄唑凝胶晨起外用,每日1次,维A酸乳膏,每晚1次;对照组85例,采用联苯苄唑凝胶晨起外用,每日1次。疗程4周,复诊时记录疗效和不良反应。结果:治疗后第15天和第29天治疗组有效率分别为80.61%、95.92%,对照组有效率分别为75.29%、85.88%,第29天两组疗效比较差异有显著性(P<0.05)。两组病例不良反应均少,未影响治疗。结论:联苯苄唑凝胶联合维A酸乳膏治疗马拉色菌毛囊炎疗效优于单用联苯苄唑凝胶。

OBJECTIVE To evaluate the clinical and mycological efficacy of the topical therapy by bifonazole gel and bifonazole gel for Malassezia folliculitis. METHODS The patients were randomly divided into two groups： 98 cases of treatment group were given bifonazole gel externally in the morning, once for every day and tretinoin cream, once for every evening; 85 patients of the control group were only given bifonazole gel externally in the morning, once for every day. 4 weeks were taken as a course of treatment. The efficacy and the adverse reactions were recorded during the referral. RESULTS 15 days and 29 days after the treatment, the efficiency in the treatment group were 80. 61 % and 95.92% respectively, while the efficiency in the control group were 75.29% and 85.88%. The difference of the efficacy between the two groups was significant after 29 clays treatment. （The P value is less than 0. 05）. Both of the two groups had little adverse reactions and it didn＇t affect the treatment. CONCLUSION The topical therapy by bifonazole gel and tretinoin ointment for Malassezia folliculitis is better than the single-use of bifonazole gel.