摘要
目的:观察补肾活血中药配合免疫抑制剂强的松治疗抗精子抗体(AsAb)阳性不孕患者的临床疗效。方法:将80例患者随机分为治疗组55例和对照组25例。治疗组用补肾活血中药结合强的松治疗,对照组用强的松治疗。观察临床疗效并检测AsAb与自然杀伤细胞(NK细胞)水平。结果:治疗组临床治愈率与总有效率均明显高于对照组,差异均有非常显著性意义(P<0.01)。治疗后,治疗组与对照组AsAb分别转阴42例(76.36%)与12例(48.00%),治疗组AsAb转阴率明显高于对照组,差异有显著性意义(P<0.05),且治疗后未转阴患者AsAb滴度均较治疗前明显降低,治疗组尤为明显。治疗后2组NK细胞均较治疗前明显减少,差异均有非常显著性意义(P<0.01)。治疗后2组NK细胞测定值比较,差异有显著性意义(P<0.05),说明治疗组减少NK细胞的作用强于对照组。结论:补肾活血中药结合强的松治疗抗精子抗体阳性不孕疗效好,毒副反应少。其作用机制可能是改善机体免疫功能,清除已形成的抗体并抑制新抗体产生。
Objective:To observe the therapeutic effect of kidney-tonifying and blood-activating herbs combined with prednisone for women infertility patients with positive antisperm antibody(AsAb).Methods:Eighty qualified patients were randomized into 2 groups:55 in the treatment group received kidney-tonifying and blood-activating herbs combined with prednisone,and 25 in the control group received prednisone alone.After treatment,the therapeutic effect was evaluated,and AsAb and natural killer cells(NK) levels were detected in both groups.Results:The cure rate and total effective rate were higher in the treatment group than those in the control group,the difference being significant between the two groups(P < 0.01).After treatment,AsAb turned negative in 42(76.36%) of the treatment group and in 12(48.0 0%) of the control group,the rate for AsAb turning negative being higher in the treatment group(P < 0.05).The AsAb titer was decreased in infertility patients still with positive AsAb,and the decrease was obvious in the treatment group.NK was decreased in both groups(P < 0.01 compared with that before treatment),and the decrease in the treatment group was obvious(P < 0.0 5).Conclusion:Kidney-tonifying and blood-activating herbs combined with prednisone is effective for the treatment of women infertility patients with positive AsAb,the toxic and side effects being less.The mechanism is probably related with the improvement of immune function,the clearance of AsAb and inhibition of AsAb formation.
出处
《新中医》
CAS
北大核心
2010年第7期37-38,共2页
New Chinese Medicine
