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替硝唑温敏性阴道用原位凝胶的制备及其质量控制 被引量:3

Preparation and Quality Control of Tinidazole T-sensitive In-situ Gel for Vaginal Application
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摘要 目的:制备替硝唑温敏性阴道用原位凝胶,并对其体外性质进行考察,为其体内研究奠定基础。方法:以泊洛沙姆P407与P188为基质,用冷法制备替硝唑原位凝胶。对其胶凝温度、胶凝强度及生物黏附性等主要物理性质进行考察,并对其质量进行控制。结果:本品具有合适的胶凝温度,胶凝强度理想,生物黏附性较强,适合阴道给药。主要质量评价指标简单易行,符合相关规定。结论:替硝唑温敏性阴道用原位凝胶制备简单,性质理想,值得进一步研发。 Objective: To prepare tinidazole T-sensitive in-situ gel for vaginal application and study its quality in vitro in order to lay foundation for the study in vivo. Method: Tinidazole in-situ gel was prepared by cooling method,peloxmer P407 and P188 were used as base. The properties of the gel,including gelling temperature, gelling strength and bio-adhesive were studied and the quality of the gel was also controlled. Result: The main properties of the gel were all promising for vaginal application. The quality of the gel in vitro met the rel- ative rtdes. Conclusion: Tinidazole T-sensitive in-situ gel with simple preparation and good quality is valuable to be studied further.
作者 罗丽萍 何文
出处 《中国药师》 CAS 2010年第7期957-958,共2页 China Pharmacist
关键词 替硝唑 温敏性 原位凝胶 质量控制 Tinidazole T-sensitive In-situ gel Quality control
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