摘要
目的:建立高效液相色谱法测定"派莎"防晒霜中三种化学吸光剂Parsol 1789(丁基甲氧基二苯甲酰甲烷)、ParsolMCX(甲氧基肉桂酸辛酯)、Parsol 5000(3,4-甲基亚苄基-樟脑)的含量。方法:色谱柱:Dimonsil C_(18)(200 mm×4.6 mm,5μm);流动相∶甲醇∶四氢呋喃∶水∶高氯酸(60∶100∶80∶0.05);流速:1 ml·min^(-1);检测波长:310,357 nm;柱温:25℃。结果:三种化学吸收剂分离度好,不受基质干扰,Parsol 1789在0.0016～0.020l mg·ml^(-1),Parsol MCX在0.754 0～0.769 0 mg·ml^(-1),Parsol 5000在0.179 0～0.188 9 mg·ml^(-1)范围内线性关系良好(r值分别为0.9998,0.9997,0.9996),平均回收率分别为99.73%,99.81%,99.41%,RSD分别为1.68%,0.17%,0.22%。结论:该测定方法操作简便,快捷,可靠性高,重复性好,可作为"派莎"防晒霜的质量控制方法。
Objective： To establish a method for detecting three chemical absorption agents Parsol 1789 、Parsol MCX and Parso15000 in ＂paisha＂ sun-screening by HPLC. Method： The Diamonsil Cls （200 mm ×4.6 mm,5 μm） colunm was used. The mobile phase was methanol-tetrahydrofuran-water-perchloric acid （60： 100： 80： 0. 05 ） , the flow rate was 1.0 ml. rain- 1 ,the detective wavelength was 310 and 357 nm,and the column temperature was 25 ℃. Result： The calibration curves of Parsol 1789 ,Parsol MCX and Parsol 5000 were linear within the range of 0. 001 6-0. 020 1,0. 754 0-0. 769 0 and 0. 179 0-0. 188 9 mg· ml ^-1 with good linearity （ r = 0. 999 8,0. 999 7,0. 999 6） ,and the average recoveries were 99. 73% ,99. 81% ,99. 41% （RSD = 1.68% ,0. 17% ,0. 22% ） ,respectively. Conclusion： The method is convenient,accurate and reproducible,which can be used in quality control of ＂paisha＂ sun-screening.
出处
《中国药师》
CAS
2010年第7期990-991,共2页
China Pharmacist
