洛美沙星、哌拉西林/他唑巴坦在转化糖电解质注射液中的配伍稳定性考察

Stability Study of Lomefloxacin Aspartate,Piperacillin Sodium and Tazobactam Sodium with Multiple Electrolytes and Invert Sugar Injection

目的:考察门冬氨酸洛美沙星、哌拉西林钠/他唑巴坦钠分别与转化糖电解质注射液配伍的稳定性,为临床合理用药提供科学依据。方法:在室温条件下,将这两种注射用抗生素分别与转化糖电解质注射液配伍,在8 h内,观察各配伍溶液的pH和外观变化,并采用HPLC法测定各配伍溶液中主药成分的相对含量。结果:门冬氨酸洛美沙星、哌拉西林钠/他唑巴坦钠分别与转化糖电解质注射液配伍后,pH、外观无明显变化,相对含量分别在96%及99%/96%以上。结论:门冬氨酸洛美沙星、哌拉西林钠/他唑巴坦钠在室温下与转化糖电解质注射液的配伍液在8 h内稳定。

Objective ： To investigate the stability of lomefloxacin aspartate, piperacillin sodium and tazobactam sodium, which two kinds of antibiotics for injection in multiple electrolytes and invert sugar injection and to provide a scientific basis for rational use of drug in clinical practice. Method： The changes of pH values and external appearances of the two kinds of antibiotics respectively mixed with multiple electrolytes and invert sugar injection were observed and their relative contents were determined by HPLC within 8 h after mixing at room temperature. Result： No marked change were noted in the relative contents, appearance and pH values of lomefloxacin aspartate, piperacillin sodium/tazobactam sodium mixed with multiple electrolytes and invert sugar injection. Conclusion： Lomefloxacln aspartate, piperacillin sodium/tazobactam sodium can be used within 8 h after mixing with multiple electrolytes and invert sugar injection at room temperature.