外科围手术期抗菌药应用干预研究

Interventional Study on Use of Antibioties for the Surgical Perioperative Period

目的:促进外科围手术期抗菌药合理应用。方法:临床药师负责抗菌药物知识培训、应用指导及动态监测,医院感染管理科加强管理考核,管教结合,综合干预,使外科围手术期抗菌药应用持续改进。结果:与对照组比,干预组清洁手术一代头孢使用率明显提高(P<0.01),三代头孢、喹诺酮类使用率明显降低(P<0.01),术前0.5～2 h首次用药率明显升高(P<0.01),术后平均用药天数明显减少(P<0.01);清洁-污染手术喹诺酮类使用率明显降低(P<0.01),术后持续用药≤24 h病例数明显增加(P<0.05);两组术后并发感染和存在感染征象的发病率无差异(P>0.05)。结论:临床药师与医院感染管理科联合干预,对外科围手术期抗菌药合理应用安全、有效。

Objective： To promote rational use of antibiotics for the Surgical Perioperative Period. Method： The clinical pharmacist was responsible for the training and direction of antibiotics application, while the office of nosocomical infection control was strengthed the management. Result： Contrast the control group, the application of 1 ＇ st generation of eephalosporins and before the operation 0. 5-2 h of the interventional group of clean surgery were significantly improved （P 〈 0. 01 ）, and the application of 3＇ rd generation of cephalosporins and quinolones and the average days of antibiotics application after the operation were significantly decreased （P 〈0.01 ）. The application of quinolones were significantly decreased （P 〈 0. 01 ）, and the cases of antibiotics application after the operation within 24 h were significantly improved of clean-dirty surgery （ P 〈 0.05 ）. While the infections diagnosed after operation had no statistical differences between groups （P 〉 0. 05 ）. Conclusion： Combined intervention from the clinical pharmacist and the office of nosoeomical infection control was safety and effective to the use of antibiotics for surgical perioperative period.