伊托必利对餐后不适综合征患者胃电图与胃排空率的影响

Impact of Itopride Hydrochloride Tablets on EGG and Gastric Emptying Rate of Patients with Postprandial Distress Syndrome

目的:评价盐酸伊托必利片对餐后不适综合征患者胃电活动和胃排空率的影响。方法:将HP检测阴性的42例餐后不适综合征患者随机分为治疗组(铝碳酸镁片+伊托必利片)22例和对照组(铝碳酸镁片)20例,疗程均为4周,治疗前后分别检查胃电图、胃排空率,比较两组各指标的改变有无差异。结果:治疗组:餐后/餐前功率比、反应面积较治疗前显著提高(P<0.05),胃电节律紊乱百分比治疗前后差异无统计学意义(P=0.07);胃排空率较治疗前显著提高(P<0.05)。对照组:治疗前后餐后/餐前功率比、反应面积、胃电节律紊乱百分比差异无统计学意义;胃排空率治疗前后比较差异无统计学意义。结论:伊托必利能显著提高餐后不适综合征患者的胃排空率、餐后/餐前功率比、反应面积,对餐后不适综合征患者有较好的治疗作用。

Objective：To evaluate the impact of itopride hydrochloride tablets on the EGG and gastric emptying rate of patients with postprandial distress syndrome（PDS）.Methods：A total of 42 HP-negative patients with PDS were randomly divided into treatment group（n=22,aluminum magnesium carbonate tablets plus itopride tablets） and control group（n=20,aluminum magnesium carbonate tablets）,who were treated for 4 weeks.Before and after treatment,EGG and gastric emptying rates of the patients in the two groups were examined and compared.Results：In the treatment group,the postprandial/fasting power ratio,response area,and gastric emptying rate were more significantly increased than those before treatment（P〈0.05）,there was no statistical difference in the percentage of gastric dysrhythmia between before and after treatment（P = 0.07）;In the control group,there were no statistical differences in the postprandial/fasting power ratio,response area,gastric emptying rate and the percentage of gastric dysrhythmia between before and after treatment.Conclusion：Itopride can significantly increase the rate of gastric emptying,the postprandial/fasting power ratio and the response area of the PDS patients,with a better therapeutic effect.