小剂量替勃龙对围绝经期及绝经后妇女颈动脉粥样硬化的影响
被引量:5
摘要
心脑血管疾病是中老年患者的主要死亡原因。围绝经期及绝经后妇女体内的性激素水平迅速下降,使血脂代谢异常,导致围绝经期及绝经后妇女心脑血管疾病的发病率增高。目前,雌激素对于预防女性冠心病的作用尚有争议,本研究目的是通过比较应用小剂量替勃龙与未应用替勃龙的围绝经期及绝经后妇女体内的性激素、血脂水平以及颈动脉血流超声影像学特征,探索理想、有效的低剂量激素治疗方案,达到降低中老年妇女心血管疾病的发生率和死亡率、改善生命质量、预防疾病的目的。
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2010年第6期452-454,共3页
Chinese Journal of Obstetrics and Gynecology
参考文献6
-
1李健初,袁光滑,柳文仪,等.血管和浅表器官彩色多普勒超声诊断学.3版.北京:北京医科大学协和医科大学联合出版社,1999:133.
-
2Vrablik M,Fait T,Kovar J,et al.Oral but not transdermal estrogen replacement therapy changes the composition of plasma lipoproteins.Metabolism,2008,57:1088-1092.
-
3Christodoulakos GE,Lambrinoudaki IV,Economou EV,et al.Differential effect of hormone therapy and tibolone on lipids,lipoproteins,and the atherogenic index of plasma.Cardiovasc Pharmaco1,2006,47:542-548.
-
4Rasulo FA,De Peri E,Lavinio A.Transcranial Doppler ultrasonography in intensive care.Eur J Anaesthesiol Suppl,2008,42:167-173.
-
5Carranza-Lira S,Cuan-Martinez JR,Rosales-Ortiz S.Brachial artery responses in menopausal women using tibolone.Int J Gynecol Obstet,2008,101:43-46.
-
6Seeger H,Kloosterboer HJ,Studen M,et al.In vitro effects of tibolone and its metabolites on human vascular coronary cells.Maturitas,2007,58:42-49.
同被引文献39
-
1谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:118-119.
-
2O'Keefe JH,Kim SC,Hall RR,et al.Estrogen replacement after coronary angioplasty in women.[J].Am Coll Cardiol,1997,29:1-5.
-
3Walera DD,Alderman EL,Hsia J,et al.Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary athemsclemsis in postmenopausal women:a randomized controlled trial[J].JAMA,2002,288 (19):2432-2440.
-
4Ziaei S,Moghasemi M,Faghihzadeh S.Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women[J].Climacteric,2010,13 (2):147-156.
-
5Nijland EA,Weijmar-Sehuhz WC,Nathorst-Boos J,et al.Tibolone and transdermal E2/NETA for the treatment of female sexual dysfunction in naturally menopausal women:results of a randomized active-controlled trial[J].Sex Med,2008,5 (3):646-656.
-
6Sanjuan A,Castelo-Branco C,Colodrbn M,et al.Effects of estradiol,cyproterone acetate,tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fedrabbits[J].Maturitas,2003,45 (1):59-66.
-
7Christodouhkos GE,Iambrinoudaki IV,Economou EV,et al.Differential effect of hormone therapy and tibolone on lipids,lipoproteins,and the atherogenic index of plasma[J].Cardiovasc Pharmacol,2006,47 (4):542-548.
-
8Lazzeroni M,Macis D,Decensi A,et al.The effect of transdermal estradiol or oral conjugated oestrogen and fenretinide versus placebo on haemostasis and cardiovascular risk biomarkers in a randomized breast cancer chemoprevention trial[J].Ecancermedicalscience,2008,2:67.
-
9Campisi R,Marengo FD.Cardiovascular effects of tibolone:a selective tissue estrogenic activity regulator[J].Cardiovasc Drug Rev,2007,25:132-145.
-
10Ribeiro F,Alves AJ,Teixeira M,et al.Endothelial function and atherosclerosis:circulatory markers with clinical usefulness[J].Rev Port Cardiol,2009,28 (10):1121-1151.
引证文献5
-
1秦柳平.替勃龙联合更美宁胶囊治疗围绝经期综合征临床观察[J].中国医药导刊,2012,14(7):1194-1195. 被引量:1
-
2杜冠华,王颖,尚敏捷.更宁汤治疗绝经综合征56例疗效观察[J].新中医,2014,46(6):135-137. 被引量:1
-
3雷玲.替勃龙对围绝经期妇女血管内皮功能的影响[J].山西医科大学学报,2014,45(10):964-967. 被引量:3
-
4王红艳.两种激素补充治疗绝经期综合症的疗效比较[J].生物技术世界,2016,13(2):213-213. 被引量:1
-
5张佩雪,王以新,冯妍,张淼淼.替勃龙联合他汀类药物对围绝经期血脂异常女性脂质代谢影响的研究进展[J].中国医药,2017,12(6):954-957. 被引量:9
二级引证文献15
-
1李冀,潘明月,李想,王晓雨,付强.肾阴虚型围绝经期综合征临床研究现状[J].辽宁中医药大学学报,2021,23(11):1-4. 被引量:2
-
2夏冬琴,李荣亨.中成药治疗女性更年期综合征综述[J].实用中医药杂志,2015,31(5):468-470. 被引量:5
-
3曹珊珊,周镇.艾灸治疗围绝经期综合征的临床疗效观察[J].中国性科学,2016,25(3):93-96. 被引量:11
-
4周芝灵,杨根兰,郑德美.替勃龙小剂量替代治疗对绝经后妇女动脉粥样硬化的影响研究[J].基层医学论坛,2017,21(17):2187-2188. 被引量:1
-
5郝宇鸣,张颖佳,徐丽华,李际春,张宁梅,郎淑慧.围绝经期女性Th1/Th2平衡与内皮功能损伤的关系研究[J].中国妇幼保健,2018,33(13):3026-3029. 被引量:1
-
6冯妍,王以新,张佩雪,张淼淼,康晨瑜.血脂康对围绝经期高脂血症患者血脂代谢的影响[J].中国医药,2018,13(10):1441-1444. 被引量:6
-
7伍雯莹,胡静,熊莉.坤泰胶囊联合尼尔雌醇治疗对更年期综合征患者性激素和血脂水平的影响[J].中国医药,2018,13(11):1725-1729. 被引量:21
-
8陈海萍.复方甲羟孕酮和替勃龙补充疗法治疗绝经期综合征的临床分析[J].药品评价,2016,13(22):23-24.
-
9焦宏伟.激素替代疗法对围绝经期综合征合并肥胖症患者血脂水平的影响[J].临床药物治疗杂志,2019,17(3):74-78. 被引量:15
-
10李秋芳.高压氧联合药物治疗对围绝经期女性血脂、血液流变学的影响[J].中外女性健康研究,2020(11):90-90.
-
1宋黎,李妍平,毛希宏,唐太昆.神经内镜控制下锁孔入路治疗高血压性脑出血[J].云南医药,2011,32(1):30-32. 被引量:3
-
2张红彤.难治性肾病综合征临床治疗观察[J].中外医学研究,2015,13(29):84-85. 被引量:4
-
3黄岚.女性更要重视冠心病[J].家庭医药(就医选药),2009(5):28-28.
-
4王文佳(综述),田野(审校).肾移植术后血脂代谢异常的研究进展[J].国际泌尿系统杂志,2012,32(1):90-93. 被引量:1
-
5郑朝晖.126例2型糖尿病肾病患者脂蛋白(a)变化与肾损害[J].中原医刊,2006,33(13):57-57. 被引量:1
-
6李保春,周卫强,崔若兰,于建平.尿毒症病人血脂代谢异常38例检测分析[J].人民军医,1993,36(9):53-54.
-
7杨进刚,杨跃进.女性冠心病特点及介入治疗进展[J].心血管病学进展,2011,32(2):141-143. 被引量:21
-
8商敏,杨欣,栾艳秋,彭向丽,付纯,孟志新,张娟.应用低剂量激素治疗预防围绝经期妇女骨质疏松症的观察研究[J].中国骨质疏松杂志,2005,11(4):423-426. 被引量:7
-
9陈国栋,陈立中,陈白莉,邱江,李军,王长希,费继光,邓素雄,傅茜,黄刚,张磊.低剂量激素方案在肾移植中应用的疗效和安全性[J].中华肾脏病杂志,2009,25(12):948-949. 被引量:1
-
10绝经后激素疗法对绝经期妇女的心血管风险差异[J].中国处方药,2007(6):61-61.