氟伐他汀对急性脑梗死患者血清抵抗素的影响

Effect of fluvastatin on serum concentration of resistin in patients with acute cerebral infarction

目的观察氟伐他汀对急性脑梗死(ACI)患者血清抵抗素水平的影响及意义。方法 ACI患者78例,分为对照组(42例)和治疗组(36例)。对照组患者给予常规药物治疗2 wk;治疗组患者在常规治疗的基础上加用氟伐他汀40 mg,每日1次,口服,治疗2 wk。所有研究对象均测定治疗前后的高敏C-反应蛋白(hs-CRP)和抵抗素,并评定神经功能缺损程度(NDS)评分。结果与治疗前对比,对照组和治疗组患者治疗后的hs-CRP和抵抗素水平均明显下降(P<0.05),但是治疗组较对照组下降更为显著(P<0.05);对照组和治疗组治疗后的NDS均较治疗前下降,但是治疗组NDS的下降较对照组更为显著(P<0.05)。结论氟伐他汀能降低ACI患者抵抗素水平,并有助于其神经功能的恢复。

AIM To observe the effect and significance of fluvastatin on serum concentration of resistin in patients with acute cerebral infarction（ACI）.METHODS Seventy-eight patients with ACI were divided into control group（n = 42） and treatment group（n = 36）.Patients in the control group were given conventional medicine treatment for 2 wk,and patients in the treatment group given combined with conventional medicine treatment and oral fluvastatin 40 mg.d-1 for 2 wk.The levels of high sensitivity C-reactive protein（hs-CRP） and resistin were measured with the evaluation of the scores of neurological deficit（NDS） before and after treatment in all patients.RESULTS Comparing to those before the treatment,the serum concentrations of hs-CRP and resistin were obviously reduced after the treatment in both groups（P 0.05）,however,reductions of hs-CRP and resistin after the treatment in the treatment group were more apparent than those in the control group（P 0.05）.The significant decrease of NDS scores after treatment also occurred in both groups but more reduction was shown in the treatment group（P 0.05）.CONCLUSION Fluvastatin can reduce serum concentration of resistin and improve the neurological function in patients with ACI.