黄芪与当归对血管再狭窄大鼠一氧化氮合成的影响

Effect of Astragalus Membranaceus and Angelica Sinensis on the Nitric Oxide Content in Restenosis Rats

目的观察黄芪、当归对血管内皮剥脱后再狭窄大鼠血浆一氧化氮合成的影响,探讨其防治血管再狭窄的作用与机制。方法建立内皮剥脱后血管再狭窄动物模型,应用黄芪、当归单独及联合治疗21d,进行血管形态学观察,应用Greiss试剂检测各组大鼠血浆中一氧化氮含量。结果与对照组比较,模型组内膜增生明显,一氧化氮合成明显降低;应用黄芪、当归单独及联合治疗21d后,与模型组比较,各治疗组内膜增生明显减轻,一氧化氮合成明显增加,以黄芪、当归联合应用组作用明显。结论黄芪、当归具有抑制血管再狭窄大鼠内膜增生、增加血浆一氧化氮合成的作用,以联合应用作用明显。黄芪、当归可能通过增加一氧化氮合成而发挥其防治血管内皮剥脱后再狭窄的作用。

Objective To explore the effect of Astragalus Membranaceus and Angelica Sinensis on the nitric oxide content in restenosis rats.Methods The restenosis model was established by denuding the rat aorta endothelium with balloon catheter.The pathological features of the arterial wall and the changes of the nitric oxide content in plasma were observed in the model group after twenty-one days of treatment by Astragalus Membranaceus and Angelica Sinensis.Results In model group,the content of nitric oxide declined compared with control group,while the nitric oxide concentration in the plasma of all the Astragalus Membranaceusor Angelica Sinensis-treated groups was obviously higher than that of model group.More powerful effect could be observed after co-treatment by Astragalus Membranaceus and Angelica Sinensis together.Conclusion Astragalus Membranaceus and Angelica Sinensis can promote nitric oxide synthesis,which may be the mechanism in treatment of restenosis.