充血性心力衰竭患者血浆脂联素和脑钠肽的相关性研究

Association analysis of plasma levels of adiponectin and brain natriuretie peptide in congestive heart failure patients

目的探讨充血性心力衰竭(CHF)患者血浆脂联素(APN)、脑钠肽(BNP)水平的变化及临床意义。方法应用酶联免疫吸附法(ELISA)分别测定70例扩张型心肌病CHF患者治疗前、治疗后及20例正常人血浆APN和BNP水平,并进行统计学分析比较。结果①CHF组APN、BNP水平分别为(11.66±4.59)mg/L(、1079.78±550.76)ng/L明显高于正常对照组(1.38±0.47)mg/L、(59.63±22.43)ng/L(均P<0.01);②心功能Ⅱ、Ⅲ、Ⅳ级组APN分别为(5.59±1.85)mg/L、(11.27±3.00)mg/L及(15.19±3.81)mg/L,BNP水平分别为(463.78±169.50)ng/L、(917.05±290.19)ng/L及(1 595.72±481.76)ng/L,随着心功能恶化二者水平显著升高(均P<0.01)。③CHF组治疗后APN(5.88±2.55)mg/L、BNP(547.25±234.88)ng/L明显低于治疗前水平,(11.66±4.59)mg/L(、1 079.78±550.76)ng/L(均P<0.01);④CHF组血浆APN水平与BNP呈正相关(r=0.680,P<0.01)。结论 CHF患者血浆APN和BNP水平明显高于正常对照组且随着心功能恶化而显著升高。CHF患者经治疗后随心功能好转血浆APN和BNP水平可降低。CHF患者血浆APN和BNP呈正相关。

Objective To evaluate the plasma levels of adiponectin（APN） and brain natriuretic peptide（BNP） in congestive heart failure（CHF） patients and their clinical significance.Methods The levels of plasma APN and BNP were measured by enzymelinked immunosorbent assay（ELISA） before treatment and after treatment in 70 patients with CHF of dilated cardiomyopathy and 20 control subjects respectively,statistical analysis and comparison were conducted on them.Results ①The plasma levels of adiponectin（11.66±4.59） mg/L and BNP（1 079.78±550.76） ng/L in CHF patients before treatment were significantly higher compared with those in control subjects（1.38±0.47） mg/L,（59.63±22.43） ng/L（both P0.01）.②The plasma levels of adiponectin in NYHA function class Ⅱ to Ⅳ subgroup in CHF group,class Ⅱ（5.59±1.85） mg/L,class Ⅲ（11.27±3.00） mg/L,class Ⅳ（15.19±3.81） mg/L,increased with the severity of NYHA functional class（P0.01）.The plasma levels of BNP in NYHA function class Ⅱ to Ⅳ subgroup in CHF group,class Ⅱ（463.78±169.50）ng/L,class Ⅲ（917.05±290.19） ng/L,class Ⅳ（1 595.72±481.76） ng/L,increased with the severity of NYHA functional class（P0.01）.③The plasma levels of adiponectin（5.88±2.55） mg/L and BNP（547.25±234.88） ng/L in CHF patients after treatment were lower than those before treatment（11.66±4.59） mg/L,（1 079.78±550.76） ng/L（P0.01）.④There was a significant positive correlation between the plasma levels of adiponectin and BNP in CHF patients（r=0.680,P0.01）.Conclusion The plasma levels of APN and BNP in CHF patients before treatment were significantly higher compared with those in control subjects.Moreover,they increased with the severity of NYHA functional class.The levels of plasma APN and BNP in CHF patients decreased after treatment with the improvement of NYHA functional class.Meanwhile,there was a significant positive correlation between their plasma APN and BNP levels.