中高度心血管病危险的高血压病患者血清尿酸与血脂的关系

The Correlation between Serum Uric Acid and Blood Lipid among Hypertensive Patients with Moderate and High Risk of Cardiovascular Disease

为研究处于心血管病事件中度和高度危险层（简称“中危层”和“高危层”）的原发性高血压患者中血清尿酸（UA）与血脂的关系，上海市疾病预防控制中心的研究人员收集了上海市区4＋a区现场调查资料，共招募1442名符合危险分层中的中危层和高危层高血压病患者（排除糖尿病和靶器官损害的患者），其中男性占36．27％，女性占63．73％。

[Objective] To investigate the correlation between serum uric acid(UA) and lipidemia profile in essential hypertensive adults with moderate-and high-risk of cardiovascular diseases.[Methods] A total of 1 442 patients(male 36.27%,female 63.73%)without diabetes and target organ damage from 4 communities in Shanghai were selected by risk category.Of them,the proportion of moderate-and high-risk was 82.39% and 17.61% respectively.The serum levels of UA,triglyceride(TG),total cholestero(lTC),high density lipoprotein cholesterol(HDL-c),and low density lipoprotein cholesterol(LDL-c)were measured by automatic biochemical analyzer.[Results] The prevalence of hyperuricemia was 20.2% in hypertension patients(moderate-risk 19.0%,high-risk 25.6%,χ2=5.602,P=0.018).In female patients,serum uric acid level in high-risk was higher than moderate-risk(307 μmol/L vs.279 μmol/L,Z=-2.935,P < 0.01).The average blood levels of TG was raised,and HDL-c was lowered as increasing of serum UA level.The difference between high-and moderate-risk was not significant(355 μmol/L vs 351 μmol/L,Z=-0.335,P > 0.05)in male.Bivariate Spearman’ rank correlate analysis showed significant correlation of serum UA with disystolic blood pressure,TG,TC,and HDL-c.Multivariate Partial correlation analysis showed that only correlation with significance was found between serum UA and TG levels(r=0.203,P < 0.01).[Conclusion] Serum UA in hypertension patients shows trend of parallel increament with lipidemia profile.The only independent correlation is found between serum UA and TG.The results suggest that increament of serum UA in hypertensive adults may be one of the predictors of hypertension progression.