紫杉醇/顺铂联合同步放疗治疗晚期非小细胞肺癌的疗效

The curative effect of Taxol and Cisplatin concomitant with thoracic radiation therapy for patients with adwanced non-small-cell lung cancer

目的观察紫杉醇/顺铂联合同步放疗治疗晚期非小细胞肺癌的疗效及安全性。方法紫杉醇60mg/m2d1,8,15,顺铂30mg/m2,d1,8,15,28天为一周期,同时适当水化,预防胃肠道反应,共化疗3～6周期。每周期化疗前12h和3h同时服用地塞米松7.5mg和雷尼替丁0.15g。同步放疗的方案是每天1.8～2Gy,每周5d,总放疗量是64～70Gy/6.5～7周。结果 20例中有4例(20%)获得CR,8例(40%)获得PR,OOR为60%。结论紫杉醇/顺铂联合同步放疗治疗晚期非小细胞肺癌是有效的,有一定的毒副作用,但是可以耐受。

Objective Be observed the curative effect and security of mostly project of Taxol and Cispl- atin concomitant with thoracic radiation therapy for patients with adwanced non-small-cell lung cancer. Methods Ttaxol 60 mg/m2 d1,8,15 ivgtt; cisplatin 30 mg/m2 ivgtt d1,8,15, pay a great lot of water propnety at one time,defend reactivity of gastric intestines. One cycle is 28 day. For therapy 3-6cycles. At one time pay DXM 4. 5 mg and Ranitidine 0. 15 g befor chemotherapy 12 h and 3 h. In-phase radiation therapy 1.8-2 Gy everyday, five days every week, general dosage 64-70 Gy/6. 5-7 weeks. Results 4patients obtain CR（20% ） in 20 ones, while 8 patients obtain PR（40% ） and OOR 60%. Conclusion It is efficiency for Taxol and Cisplatin concomitant with thoracic radiation therapy for patients with adwanced non-small-cell lung cancer. There is some side-effect but capable acceptive.