胱抑素C联合尿蛋白电泳检测对糖尿病、高血压早期肾损害的诊断价值

The Diagnostic Value of the Early Injury of Kidney through Combining Cystatin C and Non Concentrated Proteinuria Electrophoresis to Diabetes and Hypertension

目的探讨血清半胱氨酸蛋白酶抑制剂C(Cystatin C)联合非浓缩尿蛋白电泳检测对糖尿病、高血压早期肾损害诊断的价值。方法将70例高血压、糖尿病患者根据其Cystatin C和血肌酐(SCr)尿素(Urea)检测结果分为3组:A组为三指标皆正常组23例,B组为Cystatin C异常组(SCr、Urea正常)21例,C组为三指标皆异常组26例;检测肾功能同时收集患者晨尿作非浓缩尿蛋白电泳。结果 A组仅1例出现生理性尿蛋白,22例无尿蛋白区带;B、C组仅2例无尿蛋白区带,45例出现不同类型的尿蛋白。结论 CystatinC对早期肾损害有较高的敏感性,联合非浓缩尿蛋白电泳检测对糖尿病、高血压早期肾损害的诊断有较高价值。

Objective To discuss the diagnostic value of the early injury of kidney through combining Cystatin C and the non concentrated proteinuria electrophoresis to diabetes and hypertension. Methods According to the test results of Cystatin C and SCr Urea, 70 high blood pressure patients and diabetic patients are divided into three groups. There are 23 eases in group A which three indicators are normal, in group B 21 cases whose Cystain C are abnormal but SCr, Urea are normal, 26 eases whose three indicators are abnormal in group C. While testing the renal function, we collected the patients urina sanguinis as non concentrated proteinuria electrophoresis. Results There is one ease who has physilologic proteinuria in group A, 22eases have no proteinuria zone; There are only 2 patients in urine protein-free zone in group B and C, and 45 eases with different types of proteinuria. Conclusions Cystatin C has high sensibility to the early renal impairment, so the combining Cystatin C and the non concentrated proteinuria eleetrophoresis has high diagnostic value to the early injury of kidney of diabetes and hypertension.